tumour necrosis factor-alpha

(redirected from TNF-alpha)


A gene on chromosome 6p21.3 that encodes a cytokine, primarily secreted by macrophages, which binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. TNF can induce cell death of certain tumour cell lines, and it is a potent pyrogen causing fever either directly or by stimulating interleukin-1 secretion. It is implicated in the tumour-related cachexia. It may stimulate cell proliferation and induce cell differentiation.
References in periodicals archive ?
Activation of monocytes during early stages of atherosclerosis results in the release of TNF-alpha, a mediator of inflammation (Mangge et al.
Pfizer's Enbrel is a recombinant human TNF-alpha receptor fusion protein that inhibits the activity of TNF-alpha.
Clinical study on gastric cancer susceptibility genes IL-10-1082 and TNF-alpha.
Tumour necrosis factor (TNF) gene polymorphism influences TNF-alpha production in lipopolysaccharide (LPS)-stimulated whole blood cell culture in healthy humans.
Plasma leptin and TNF-alpha levels in chronichepatitis C patients and their relationship to hepatic fibrosis.
The feasibility of monitoring NF-kappaB associated cytokines: TNF-alpha, IL-1alpha, IL-6, and IL-8 in whole saliva for the malignant transformation of oral lichen planus.
As expected, plasma TNF-alpha levels rose significantly--"a 2- to 3-fold increase" (Mathur & Pedersen)--during the control experiment.
recently demonstrated that oral strontium chloride hexahydrate (40 mg/kg and 160 mg/kg) suppressed serum TNF-alpha levels and had comparable therapeutic efficiency when compared with prednisolone in a rat ulcerative colitis model [21].
Arkan 0, Aral M, Sasmaz S, Ciragil P Serum levels of TNF-alpha, IFN-gamma, IL-6, IL-8, IL-12, IL-17 and IL-18 in ptients with active psoriasis and correlation with disease severity.
The TNF-alpha gene Nco I polymorphism influences the relationship among insulin resistance, percent body fat, and increased serum leptin levels.