tumour necrosis factor-alpha

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A gene on chromosome 6p21.3 that encodes a cytokine, primarily secreted by macrophages, which binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. TNF can induce cell death of certain tumour cell lines, and it is a potent pyrogen causing fever either directly or by stimulating interleukin-1 secretion. It is implicated in the tumour-related cachexia. It may stimulate cell proliferation and induce cell differentiation.
References in periodicals archive ?
Similar to TNF-a, our data also showed that the concentrations of CXCL8, another name of IL-8, increased in the BALF of asthmatics compared to controls and corresponded to the lung function and infiltration of neutrophils and eosinophils.
Some studies implicate that the cytokines TNF-a and IL-8 together might be involved in Th17-cell polarization or induce IL-17 production.
Follow-ups included measurement of aforementioned indices: AP diameter and cortical thickness of affected kidney, as well as TNF-a and CASPASE 3 enzyme levels in urine, three and six months after pyeloplasty.
TNF-a and caspase 3 enzyme levels were checked in healthy children, in order to have a basis for comparison with the patients group.
Amplification of cDNA through RT-PCR: TNF-a gene expression was examined in the head kidney and spleen through RT-PCR and expression under stimulation with LPS and Poly I.
Thermocycler conditions for amplification were 94degC initial denaturation for 3 minutes, 35 cycles with 94degC denaturation temperature for 30 seconds, 53degC and 54degC annealing temperature for 30 seconds for b-actin and TNF-a respectively, 72degC elongation temperature for 45 seconds.
There is robust data that serum levels of leptin, ghrelin and TNF-a correlates significantly with various cardiovascular conditions, including congenital heart diseases; 6,8,9,16 but we found different results.
Markedly increased ROS production was observed in the TNF-a groups at all the time points.
After being treated with TNF-a for 1 h, the cells were fixed for 15 min in 4% (w/v) paraformaldehyde and permeabilized by 0.