Acquired resistance to doxycycline is 2% and to TMPSMX is geographically variable (2.
5% of cases in Thailand; 14), and the chance of neurologic disease with a strain that is resistant to TMPSMX developing in a patient is low.
The use of the recommended alternative, TMPSMX
, has remained low and stable.
Whether these mutations confer resistance to TMPSMX or dapsone plus trimethoprim for PCP treatment remains unclear.
Even short-term exposure to TMP-SMX can be associated with the emergence of TMPSMX resistance, as has been demonstrated in patients with acute cystitis caused by Escherichia coli (5).
Another study demonstrated an apparent reversal of the DHPS mutant-to-wild-type ratios after the use of TMPSMX was restricted (31).
medical institutions that submit such information to an electronic database, 39% were resistant to ampicillin, 18% were resistant to TMPSMX
, and 2% were resistant to ciprofloxacin, reported Dr.