TMPRSS2

TMPRSS2

A gene on chromosome 21q22.2 that encodes an androgen-regulated transmembrane serine protease, the translocation of which to either ERG (at 21q22.3) or ETV1 (at 7p21.2) (both of which belong to the ETS transcription factor family) provides a selective mechanism for prostatic cancer initiation or, more likely, maintenance. It is strongly expressed in the small intestine.
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What's more, men who did the most vigorous exercise had a 29 percent lower risk of having tumors with a fusion of two genes-- TMPRSS2 and ERG--than those who did the least.
Several urinary markers, such as PCa antigen 3 and the TMPRSS2: ERG gene fusion or DNA methylation patterns of urinary sediment, have also been explored for use in PCa detection and management.
One such example combines the 5 UTR of TMPRSS2 to a member of the ETS transcription factor family (TMPRSS2-ETS).
Prostat kanserinde androjen bagimli transmembran serin 2 gen (TMPRSS2) ile prostat kanseri gelisiminde anahtar rol oynayan bir onkogen olan ERG geni arasinda fuzyon varligi gosterilmistir.
This test uses three different biomarkers, including urine TMPRSS2:ERG and PCA3 plus results of a serum PSA completed within the last six months (Tomlins et al., 2015).
The main genetic alterations reported for prostate cancer are as follows: (a) merging: the main merging described is the one between TMPRSS2 and ETS family verified by various NGS techniques achieving the same result, constituting a powerful tool for diagnostic PC [16-18]; (b) mutations: P53 mutation is linked in most tumor types including hereditary.
The most important genes distinguishing CTCs into the subgroups were vascular endothelial growth factor A (VEGFA; a marker that stimulates vasculogenesis and angiogenesis also relevant as therapeutic target) (17), AR (a receptor that plays a key role in the development and progression of PC and is used as therapeutic target) (18), nuclear factor [kappa]B (NF-[kappa]B; a transcription factor known to regulate AR expression and PC growth) (19), NK3 homeobox 1 (NKX3-1; an androgen-regulated transcription factor believed to act as a suppressor of the pathogenic ERG, ETS transcription factor (TMPRSS2-ERG) rearrangement] (20), and transmembrane protease, serine 2 (TMPRSS2; an androgen-regulated protease known to be contributing to regulation of cancer growth) (20) (Fig.
Cathepsins B and L activate Ebola but not Marburg virus glycoproteins for efficient entry into cell lines and macrophages independent of TMPRSS2 expression.
Comprehensive assessment of TMPRSS2 and ETS family gene aberrations in clinically localized prostate cancer.