TMPRSS2

TMPRSS2

A gene on chromosome 21q22.2 that encodes an androgen-regulated transmembrane serine protease, the translocation of which to either ERG (at 21q22.3) or ETV1 (at 7p21.2) (both of which belong to the ETS transcription factor family) provides a selective mechanism for prostatic cancer initiation or, more likely, maintenance. It is strongly expressed in the small intestine.
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What's more, men who did the most vigorous exercise had a 29 percent lower risk of having tumors with a fusion of two genes-- TMPRSS2 and ERG--than those who did the least.
Several urinary markers, such as PCa antigen 3 and the TMPRSS2: ERG gene fusion or DNA methylation patterns of urinary sediment, have also been explored for use in PCa detection and management.
One such example combines the 5 UTR of TMPRSS2 to a member of the ETS transcription factor family (TMPRSS2-ETS).
Prostat kanserinde androjen bagimli transmembran serin 2 gen (TMPRSS2) ile prostat kanseri gelisiminde anahtar rol oynayan bir onkogen olan ERG geni arasinda fuzyon varligi gosterilmistir.
This test uses three different biomarkers, including urine TMPRSS2:ERG and PCA3 plus results of a serum PSA completed within the last six months (Tomlins et al., 2015).
The main genetic alterations reported for prostate cancer are as follows: (a) merging: the main merging described is the one between TMPRSS2 and ETS family verified by various NGS techniques achieving the same result, constituting a powerful tool for diagnostic PC [16-18]; (b) mutations: P53 mutation is linked in most tumor types including hereditary.
The most important genes distinguishing CTCs into the subgroups were vascular endothelial growth factor A (VEGFA; a marker that stimulates vasculogenesis and angiogenesis also relevant as therapeutic target) (17), AR (a receptor that plays a key role in the development and progression of PC and is used as therapeutic target) (18), nuclear factor [kappa]B (NF-[kappa]B; a transcription factor known to regulate AR expression and PC growth) (19), NK3 homeobox 1 (NKX3-1; an androgen-regulated transcription factor believed to act as a suppressor of the pathogenic ERG, ETS transcription factor (TMPRSS2-ERG) rearrangement] (20), and transmembrane protease, serine 2 (TMPRSS2; an androgen-regulated protease known to be contributing to regulation of cancer growth) (20) (Fig.
Comprehensive assessment of TMPRSS2 and ETS family gene aberrations in clinically localized prostate cancer.