TMEM181

TMEM181

A gene on chromosome 6q25.3 that encodes a G protein-coupled receptor on the cell surface, which mediates action of cytolethal distending toxins.
References in periodicals archive ?
In particular, mutagenized KBM7 cells were treated with Escherichia coli-derived CDTs and resistant clones were isolated, leading to identification of insertions in the sphingomyelin synthase 1 and the putative G protein-coupled receptor TMEM181, suggesting that this molecule may serve as a surface receptor for the toxin [43,44].
coli) putative G protein-coupled receptor TMEM181 identified as toxin receptors Clostridium Lipolysis-stimulated lipoprotein and the difficile and low-density lipoprotein receptor- perfringens toxins related protein 1 identified as the receptors for the bacterial toxins, respectively Ebola virus HOPS proteins and the Niemann-Pick Cl (NCP1) transporter identified as endosomal receptors that mediate cytosol access Lassa virus LAMP1, lysosomal-associated membrane protein 1 identified as an essential host factor mediating virus release to cytosol Adeno-associated 46 cell host factors identified, virus (AAV) serotype including heparin sulfate proteoglycan 2 biosynthesis and intracellular transport genes.