Because the KLK8 gene is predicted to encode for a secreted serine protease, this enzyme may have value as a biomarker, similar to hK3 (PSA) (3), hK6, hK10 (NES1), and hK11 (TLSP) (4-7).
(4) Nonstandard abbreviations: hK, human kallikrein; KLK, kallikrein gene; PSA, prostate-specific antigen; NES1, normal epithelial cell specific 1; TLSP, trypsin-like serine protease; AcNPV, Autographa californica nuclear polyhedrosis virus; and SDS-PAGE, sodium dodecyl sulfate-polyacrylamide gel electrophoresis.
Genomic organization, mapping, tissue expression, and hormonal regulation of trypsin-like serine protease (TLSP PRSS20), a new member of the human kallikrein gene family.
(a) Official Name when first First GenBank First kallikrein cloned submission publication name KLK4 Prostase AF113141 (24) KLK5 KLK-L2 AF135028 (23) KLK6 Neurosin D78203 (mRNA) (73) AF149289 (Full gene) (22) KLK7 HSCCE (b) L33404 (mRNA) (74) AF166330 (Full gene) (13) KLKS Neuropsin AB009849 (75) KLK9 KLK-L3 AF135026 (76) KLK10 NES1 NM 002776 (mRNA) (58) AF055481 (Full gene) (77) KLK11 TLSP ABO12917 (mRNA) (78) AF164623 (Full gene) (79) KLK12 KLK-L5 AF135025 (28) KLK13 KLK-L4 AF135024 (14) KLK14 KLK-L6 AF161221 (27) KLK15 KLK15 AF242195 (7) (a) A brief history describing the discovery of the three classic kallikreins has been published in a recent review (54).
Genomic organization, mapping, tissue expression and hormonal regulation of trypsin-like serine protease (TLSP
PRSS20), a new member of the human kallikrein gene family.