CXCL12

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CXCL12

A gene on chromosome 10q11.1 that encodes a stromal cell-derived alpha chemokine of the intercrine family which, once bound to its receptor, CXCR4, activates lymphocytes, an interaction that has been implicated in the metastasis of breast and other cancers.

Molecular pathology
CXCL12 mutations are associated with resistance to HIV-1 infections.
References in periodicals archive ?
Some of the initiatives we reviewed, such as TLSF, for example, developed highly effective partnerships with prestigious and influential organisations like UNESCO (UNESCO, 2005b),.
For example, some initiatives, such as TLSF (UNESCO, 2005) and SEEPS (Shallcross, 2004), targeted a large (regional or international) audience, mainly through the dissemination of a resource through an online medium, while other initiatives, such as LSE (Fein, Heck & Ferreira, 1997) and ACTs (Tilbury, Podger & Reid, 2004), sought to engage a small audience intensely, thereby achieving small-scale but often longer lasting change, as opposed to broad change.