DDR2

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DDR2

A gene on chromosome 1q23.3 that encodes a receptor tyrosine kinase belonging to the subfamily homologous to Dictyostelium discoideum protein discoidin (Discoidin Domain-containing Receptor); it is required for normal bone development. DDR2 regulates osteoblast differentiation and chondrocyte maturation via a MAP kinase-signalling pathway, activating the transcription factor RUNX2; it regulates remodelling of the extracellular matrix by upregulating collagenases MMP1, MMP2 and MMP13, facilitating cell migration and tumour cell invasion. DDR2 promotes fibroblast migration and proliferation, contributing to wound healing.
References in periodicals archive ?
Depending on the structure of the underlying network, some parts of the TKT might be deeply nested, with a small number of leaves, which leads to an increased rekeying overhead.
This change implies moving beyond the application of tests such as the TKT or the QPT, in the case of teachers; or beyond the knowledge tests (Pruebas Saber), in the case of high school students, to the development of better, more varied, and more trustworthy assessment mechanisms for both teachers and students (Cardenas, 2006; Gonzalez, 2007).
However, posttranscriptional regulation appears to play a significant role in the expression of corneal crystallins aldehyde dehydrogenase IIIA1 (Aldh3a1) and transketolase (Tkt), which constitute roughly 50% and 10% of the water-soluble protein, respectively, and only about 1% each of the total mRNA in the adult cornea [31].
The course is a package offer along with the Cambridge TKT exam also administered by the British Council and TKT trainees are given a discounted exam fee.
FIFTEEN Bahraini senior school teachers were honoured yesterday at the British Council's headquarters in Khamis, after passing the University of Cambridge English for Speakers of Other Languages (ESOL) Examinations' Teaching Knowledge Test (TKT).
In fact, several teachers in Abu Dhabi recently took the Teaching Knowledge Test (TKT) to aid their English language teaching.
While Amgen's process for the manufacture of EPO relied on an exogenous DNA sequence coding for EPO (which was introduced into the host cell), the TKT method involved gene activation of an endogenous DNA sequence by an exogenous upstream control sequence.
The Gattman virus, which is believed to have been written by members of the "Ready Rangers Liberation Front" (rRlf) and "The Knight Templars" (TKT) virus-writing gangs, works by infecting IDC files.
The EU Merger Task Force's market investigation concluded that the proposed transaction, leading to a vertical integration of a formerly independent supplier of TKT, would not significantly impede effective competition in the European Economic Area (EEA) or any substantial part of it.aTKT is a leading naval shipyard and one of Atlas' biggest clients.
According to the company, Nortel worked with German communications consultant tkt teleconsult to deploy a WiMAX network that allowed NEW Energie to provide broadband wireless connections to a selection of small businesses and consumers in the town of Erkelenz in North Rhine-Westphalia, Germany, at speeds of up to 10Mb/s.
(86) In this particular case, Kirin-Amgen was pursuing a number of parties for infringing its EPO patent, including the TKT group, which had found a mechanism to activate the EPO gene in situ in a human cell.
When the two methods resulted in the isolation of strain pairs of different FQ susceptibilities, analysis of the gyrA, aspA, glnA, gltA, glyA, pgm, and tkt genes from the two isolates revealed that most of these pairs (19 of 21) also differed at two or more nucleotides (data not shown).