DDR2

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DDR2

A gene on chromosome 1q23.3 that encodes a receptor tyrosine kinase belonging to the subfamily homologous to Dictyostelium discoideum protein discoidin (Discoidin Domain-containing Receptor); it is required for normal bone development. DDR2 regulates osteoblast differentiation and chondrocyte maturation via a MAP kinase-signalling pathway, activating the transcription factor RUNX2; it regulates remodelling of the extracellular matrix by upregulating collagenases MMP1, MMP2 and MMP13, facilitating cell migration and tumour cell invasion. DDR2 promotes fibroblast migration and proliferation, contributing to wound healing.
References in periodicals archive ?
135) It is interesting to note that the TKT technology would not have come within the scope of the Australian patent because the primary claim in Australia was limited to expression of an exogenous DNA sequence.
TKT is conducting an open-label Phase I/II study to evaluate the safety and clinical activity of GA-GCB.
At conflict is whether Amgen's patents cover the protein, as TKT claims, or the methods used to manufacture the protein, as Amgen maintains.
9] TKT (ticketing): If applicable, indicates the last date by which all tickets on the fare must be issued.
TKT hasn't disclosed how it makes the enzyme, but the firm may be using its controversial technology known as gene activation.
5p drop to 539p as Credit Suisse First Boston (CSFB) cut its rating on the stock to neutral from outperform amid disappointment about its acquisition of US biotech firm TKT.
Cambridge, MA) said that the House of Lords has ruled in favor of TKT in a United Kingdom patent infringement suit involving TKT and Sanofi-Aventis against Kirin-Amgen, Inc.
Amgen's scuffle with TKT over one of its patents isn't new.
Shares in the airport were divided between the Hellenic Republic (55%) and the Hochtief consortium (45%), the latter comprising Hochtief, ABB, Krantz TKT and Flughafen Athens Spata Projektgesellschaft.
ABC and TKT have already faced union problems in some cities.
During her tenure at TKT, she developed and implemented a variety of communication strategies to support high profile events and expand its investor relations program and was involved in bringing closure to the company's $1.
Eboi Razon (67) and FGA President and Riyadh Area Manager of Saudi TKT Co.