EGR1

(redirected from TIS8)

EGR1

A gene on chromosome 5q31.1 that encodes a DNA-binding nuclear protein of the EGR family of C2H2-type zinc-finger transcriptional regulators. EGR1 activates the transcription of target genes whose products are required for mitogenesis and differentiation.
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NGFI-A (also known as Egr1, krox24, zif/268, and TIS8), a transcription factor belonging to the early growth response family [150], is associated with stabilisation of LTP and learning [151, 152].