SUV4- (PHF8) 20H2) Fosforilacion Serina/ Fosforilasa de H3S10, H3T3 treonina proteina quinasa (Haspin) Descompactacion Acetilacion de HAT (TIP60
) Deacetilasa lismas en H3 y (Sirt2) H4 Trimetilacion HMT (Set1) Desmetilasa de H3K4 (Jhd2) Fuente: adaptado de (54), (55) y (58).
Among the most active HATs in mammals are found cAMP response-element binding protein (CREB) binding protein (CBP), p300, p300/CREB binding protein-associated factor (PCAF), and HIV Tat interactive 60-kDa protein (Tip60
Robson, "Cellular functions of TIP60
," The International Journal of Biochemistry & Cell Biology, vol.
A number of chromatin-remodeling complexes contain Ruvbl1, like INO80 complex, TIP60
complex, and SWR1 complex, to facilitate the assembling and maintenance of the catalytic activity of ATPase [36, 38, 44].
HAT complexes of the MYST family are named after the four founding family members, MOZ, Ybf2 (Sas3), Sas3, and Tip60
Abbreviations: ER: estrogen receptor; HAT: histone acetyltransferase; LBD: ligand-binding domain; MYST: MOZ, Ybf1/Sas3, Sas2 and Tip60
; Hbo1: a histone acetyltransferase binding to origin recognition complex 1 (ORC1); KAT7: lysine acetyltransferase 7.
Sirt1 physically interacts with Tip60
and negatively regulates Tip60-mediated acetylation of H2AX.
HDAC2 was generously provided by Ito Kazuhiro (Imperial College London), and PCAF, HMUF, and TIP60
were kindly provided by Bertrand Joseph (Karolinska Institutet) (see Supplemental Material, "Plasmids").
Additionally, TRIM 29 has been shown to interact with the p53 pathway, either by a direct interaction with p53 itself (46) and/or by interacting with the Tat-interacting protein 60 (Tip60
), resulting in suppression of p53 activity.
Based on sequence conservation within the HAT domain and substrate (histone) specificity, nuclear HATs can be grouped into four different families, Gcn5/PCAF (includes yeast Gcn5 and its human ortholog, PCAF), MYST (includes MOZ, Ybf2/Sas3, Sas2, and Tip60
), p300/CBP (includes human paralogs p300 and CBP), and Rtt109 (named for regulator of Ty1 transposition gene product 109) [3, 34].
Brauns-Schubert et al., "Phosphorylation of Tip60
by GSK-3 Determines the Induction of PUMA and Apoptosis by p53," Molecular Cell, vol.
Sato et al., "TRIM29 negatively regulates p53 via inhibition of Tip60
," Biochimica et Biophysica Acta-Molecular Cell Research, vol.