KAT5

(redirected from TIP60)

KAT5

A gene on chromosome 11q13 that encodes a catalytic subunit of the NuA4 histone acetyltransferase complex (NuA4 HAC) involved in transcriptional activation of genes, principally by acetylating nucleosomal histones H4 and H2A. The NuA4 HAC may be required for activating transcription programmes of oncogene and proto-oncogene mediated growth induction, tumour suppressor-mediated growth arrest/replicative senescence, apoptosis, and DNA repair. Post-translational modifications include sumoylation, phosphorylation, ubiquination and autoacetylation.
References in periodicals archive ?
HDAC2 was generously provided by Ito Kazuhiro (Imperial College London), and PCAF, HMUF, and TIP60 were kindly provided by Bertrand Joseph (Karolinska Institutet) (see Supplemental Material, "Plasmids").
PLIP es una proteina derivada del mismo gen codificante de TIP60/HTATIP (del ingles HIV-1 TAT-interacting protein, 60-KD), TIP60 es una histona-desacetilasa y una variedad por corte y empalme alternativo del ARNm produce una proteina con actividad reguladora para la cPLA2alfa.