ZBTB7B

(redirected from THPOK)

ZBTB7B

A gene on chromosome 1q21.3 that encodes a protein which plays a key role in the instruction of lymphoid stem cells to develop into CD4 T cells. ZBTB7B is a transcriptional repressor of COL1A1 and COL1A2; it may act as a repressor of fibronectin and possibly other extracellular matrix genes.
References in periodicals archive ?
At the transcriptional level, the development of NKT17 cells is repressed by ThPOK and driven by ROR[gamma]t expression [103-105].
Using mice, the team showed that turning off this transcription factor (ThPOK) enabled the helper cells in the body's peripheral areas, like the blood, spleen and the intestine, to override their original programming and to become killer T cells.
Pedroni et al., "Th inducing POZ-Kruppel Factor (ThPOK) is a key regulator of the immune response since the early steps of colorectal carcinogenesis," PLoS ONE, vol.
It may be also possible that Bcl11b cooperatively works with ThPok or Runx in the activation or suppression of some target genes.