thrombocythaemia type 1

(redirected from THCYT1)

thrombocythaemia type 1

A myeloproliferative disorder (OMIM:187950) characterised by increased platelets due to sustained proliferation of megakaryocytes, often leading to thrombosis and haemorrhage.

Molecular pathology
Caused by defects of THPO, which encodes thrombopoietin, a humoral growth factor required for megakaryocyte proliferation and maturation.