GPBAR1

(redirected from TGR5)

GPBAR1

A gene on chromosome 2q35 that encodes a G protein-coupled receptor for bile acid. Bile acid binding induces GPBAR1 internalisation, activation of extracellular signal-regulated kinase and intracellular cAMP production; it is believed to be involved in the suppression of macrophage functions by bile acids.

References in periodicals archive ?

The investigators further demonstrated that the bile acid receptor TGR5 mediates the effects of elevated bile acids and OCA in the nucleus accumbens, a brain region that plays a central role in reward circuitry.

Study uncovers method to treat cocaine abuse

88 - THE ROLE OF THE TGR5 RECEPTORS AND DEIODINASE II IN 3,4-METHYLENE-DIOXYMETHAMPHETAMINE (MDMA, MOLLY)-INDUCED HYPERTHERMIA.

College Student and Professional Poster Sessions 9:00 - 10:00 AM and 1:30 - 3:00 PM Lenhart Grand Ballroom - BTSU 202

Also, genetic mutations of TGR5, a G-protein-coupled receptor that functions as a cell surface receptor for BAs and regulates basal and cholinergic-induced secretion in the colon and colonic transit, can predispose to BAM [9].

Pros and Cons of the SeHCAT Test in Bile Acid Diarrhea: A More Appropriate Use of an Old Nuclear Medicine Technique

Increased levels of circulating bile acids induced by chronic high-fat feeding upregulate neuronal nitric oxide synthase (nNOS) and bile acid receptor 1 (TGR5) expression in the gastric myenteric plexus, resulting in enhanced noncholinergic relaxation and delayed gastric emptying [37].

Choosing an Animal Model for the Study of Functional Dyspepsia

Bile acids modulate innate and adaptive immunity and are involved in many metabolic and inflammatory processes mainly through activation of the nuclear receptor farnesoid X receptor (FXR), the membrane receptor TGR5, extra-cellular signal-regulated kinase (ERK), and MAP kinases signalling pathways [22].

Elevated Serum Total Bilirubin Level Is Associated with Poor Outcomes in Pediatric Patients with Sepsis-Associated Liver Injury

Dietary supplementation with the bile acid cholic acid in mice reverses HFD-induced weight gain by activating D2 and converting T4 to T3 through TGR5 receptor activation.

Adipocyte DIO2 Expression Increases in Human Obesity but Is Not Related to Systemic Insulin Sensitivity

Bile acids play their roles through specific receptors, including nuclear receptors [farnesoid X receptor (FXR), vitamin D receptor (VDR), and pregnane X receptor (PXR)] as well as membrane receptors [G-protein-coupled bile acid receptor 5 (TGR5), sphingosine-1-phosphate receptor 2 (S1PR2), and muscarinic receptor 2] [11-18], and may activate multiple signaling pathways [protein kinase B (AKT), extracellular regulated protein kinases (ERK1/2), and c-Jun N-terminal kinase (JNK)] [19-22].

Deoxycholic Acid-Mediated Sphingosine-1-Phosphate Receptor 2 Signaling Exacerbates DSS-Induced Colitis through Promoting Cathepsin B Release

The company's GI portfolio includes tenapanor for the treatment of people with irritable bowel syndrome with constipation (IBS-C), and RDX8940, a TGR5 agonist.

Ardelyx Licenses Fosun Pharmaceutical to Develop and Commercialize Tenapanor in China

Katsuma S, Hirasawa A, Tsujimoto G (2005) Bile acids promote glucagon-like peptide-1 secretion through TGR5 in a murine enteroendocrine cell line STC-1.

ILEAL INTERPOSITION SURGERY DID NOT PREVENT THE ONSET OF TYPE 2 DIABETES IN RATS

Strehle et al., "Anti-hyperglycemic activity of a TGR5 agonist isolated from Olea europaea," Biochemical and Biophysical Research Communications, vol.

Erzhi Pill[R] Repairs Experimental Liver Injury via TSC/mTOR Signaling Pathway Inhibiting Excessive Apoptosis

Mu et al., "Aberrant DNA methylation of G-protein-coupled bile acid receptor Gpbar1 (TGR5) is a potential biomarker for hepatitis B virus associated hepatocellular carcinoma," International Journal of Medical Sciences, vol.