IL10

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IL10

A gene on chromosome 1q31-q32 that encodes interleukin-10, a cytokine produced primarily by monocytes, but also by lymphocytes, which inhibits the synthesis of a number of cytokines (including IFN-gamma, IL-2, IL-3, TNF and GM-CSF) produced by activated macrophages and helper T cells. IL10 has pleiotropic effects in immunoregulation and inflammation. It downregulates expression of Th1 cytokines, MHC class-II antigens and co-stimulatory molecules on macrophages, and it enhances B cell survival, proliferation and antibody production. It can block NF-kappa B activity, and is involved in regulating the JAK-STAT signalling pathway.

Molecular pathology
IL10 mutations are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
One of the group's biggest challenges was getting restaurants to participate in the TGIF initiative, Lin said, adding that only about 5 percent of the restaurants in her town initially joined the effort.
TGIF is available on the App Store and Google Play for free.
They began brainstorming ideas, and eventually spawned the TGIF program through the Westerly Innovations Network, a student-led, nonprofit community problem-solving team.
KARACHI -- Benazir Income Support Programme (BISP) and MCR Pvt Limited Franchise of International Food chain of Pizza hut, Burger King and TGIF for the territory of Pakistan, signed a Memorandum of Understanding (MoU) to impart vocational training to the BISP beneficiaries and to provide trained labour work force to the food industry.
TGIF ended up striking a separate endorsement deal with the celebrity chef, Grinthai recalls.
Birthday and This Is How We Do, with its heavy beats, are reminiscent of Last Friday Night (TGIF).
I say TGIT because the following day is TGIF and TGIF means that there is no early morning start on Saturday.
Bul-gum is the Korean equivalent of 'TGIF', and is an excuse to down large volumes of soju on Friday evenings, CNN said.
Boy Meets World is a half-hour comedy that ran as part of ABC's 'TGIF' block for seven seasons from 1993-2000.
FRIDAY TGIF The Viper Bar & Club, Glasgow Alfredo Crolla and Stevie Foy play out the latest hits, club classics and dancefloor electro.
Friday Nights and TGIF. My sister and I were allowed to stay up as late as we wanted and camp out on the living room floor watching favorites like "Full House." It was a big deal when Mom would let us pick whatever we wanted for dinner--which was usually Burger King.
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