TGFBR1

(redirected from TGFR-1)

TGFBR1

A gene on chromosome 9q22 that encodes a transmembrane kinase of the TGFB receptor subfamily of Ser/Thr protein kinases, which forms a heteromer with type-II TGF-beta receptors and binds TGF-beta. This receptor/ligand complex phosphorylates proteins which enter the nucleus and regulate transcription of cell proliferation-related genes.

Molecular pathology
TGFBR1 mutations are associated with Loeys-Deitz aortic aneurysm syndrome.
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References in periodicals archive ?
Inflammatory response was assessed at D3 and D14 by measuring microglia/macrophage cell density using Iba-1 immunostaining and by quantification of mRNA encoding proinflammatory cytokines interleukin-1[beta] (IL-1[micro]), IL-6, interferon-[gamma] (IFN-[gamma]), tumor necrosis factor- [alpha] (TNF-[alpha]), macrophage chemoattractant protein-1 (MCP-1), and the anti-inflammatory cytokine TGF-[beta] and its receptor, TGFR-1.