TGFB3


Also found in: Acronyms.

TGFB3

A gene on chromosome 14q24 that encodes a member of the transforming growth factor beta (TGFB) family of cytokines. These multifunctional peptides up- and downregulate proliferation, differentiation, adhesion, migration, death and other functions in many cell types. TGFBs transduce their signal by binding to transmembrane growth factor receptors (TGFBR1 and TGFBR2) and their downstream effectors, the SMAD proteins; disruption of the TGFB/SMAD pathway has been implicated in various cancers. TGFB3 is involved in embryogenesis and cell differentiation.

Molecular pathology
TGFB3 mutations cause familial arrhythmogenic right ventricular dysplasia type 1.
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Variants of developmental genes (TGFA, TGFB3, and MSX1) and their associations with orofacial clefts: a case-parent triad analysis.
This study compared methylation differences and expression differences of 12 genes, including TGFB3, ACSL1, RYR1, ACOX2, PPARG2, NTN1, RIN2, MAPRE1, ADAMTS2, MYOM1, ZDHHC13, and SH3PXD2B.
Variable(s) Area Standard p value 95% confidence error interval Lower Upper bound bound miR-34a 0.854 # 0.051 <0.001 0.754 0.954 MET 0.765 # 0.059 0.005 0.648 0.881 E2F3 0.761 # 0.063 0.006 0.638 0.884 SOX2 0.571 0.094 0.479 0.388 0.755 TGFB3 0.553 0.081 0.586 0.395 0.711 DFFA 0.118 0.053 0.068 0.014 0.222 TP53INP2 0.587 0.062 0.173 0.466 0.709 Combined first 0.793 # 0.034 <0.001 0.727 0.859 three markers All combined 0.589 # 0.030 0.014 0.530 0.648 markers Bold values are statistically significant at p < 0.05.
MTHFR, TGFB3 and TGFA polymorphisms and their association with the risk of non-syndromic cleft lip and cleft palate in China.
The following 18 genes were identified from the whole genome expression profiles of spleen in GeneNetwork of female and male mice: Csf1r, FoxP3, Gata4, Ifnb1, Ifng, IL-10, IL-17a, IL-19, IL-20, IL-22, IL-22, IL-24, Nkx2-5, Tbx5, Tgfb1, Tgfb2, Tgfb3, and Tpr.
TGFBR1 and TGFBR2 pathogenic variants were initially shown to cause LDS, with subsequent pathogenic variants identified in SMAD3, TGFB2, and TGFB3. We report a case of a novel pathogenic variant in TGFBR2 and phenotype consistent with LDS [4] and demonstrate pathogenic effects on the downstream protein structure based on novel molecular modeling techniques.
Lidral et al (1997) evaluated the association of four candidate genes TGFA, TGFB2, TGFB3, homeobox 7 (MSX1) variations in a population from Philippines; however, no evidence for association of TGFA with nonsyndromic CL/P was found in non-Caucasian population (35).
EVs also express genes involved in TGF-[beta] signaling (TGFB1, TGFB3, FURIN, and ENG).
Similarly, they had longer followup after transplantation, higher expression of CDC20, CXCL6, DIABLO, GABRP, KIAA0101, ME2, MMP7, NFATC4, and TGFB3 mRNA, and lower expression of CCL19 and TRADD mRNA (Table 2).
Exposure of cells generated via this method to SHH at day 5 and to FGF8 at day 9 of terminal differentiation and further culture until day 19 in medium supplemented with AA, brain derived neurotrophic factor (BDNF), GDNF, transforming growth factor beta 3 (TGFB3), and cyclic adenosine 3',5'-monophosphate (cAMP) leads to production of Tubulin, Beta 3 Class III (TUBB3) positive neurons coexpressing TH [9].