2), but just like TGFB2
in the multiplex qRT-PCR, the YTXs induced the same effect on these three genes as the AZAs did.
Similar differences were observed for SNP rs1891467 (TGFB2
), where we noticed the differences between all comparisons with the Slovenian population, as well as between GBR and IBS.
Pathogenic variants in all 5 genes that cause LDS, TGFBR1, TGFBR2, TGFB2
, TGFB3, and SMAD3 result in loss of wild-type function of the protein product.
Hanna et al., "TGFB2
mutations cause familial thoracic aortic aneurysms and dissections associated with mild systemic features of Marfan syndrome," Nature Genetics, vol.
Endochondral Actin Focal ossification cytoskeleton adhesion VEGFA FGF2 COL11A1 ADAMTS4 FGFR1 COL3A1 PLAT4 TMSB4X COL4A1 COL10A1 GNA13 COL4A2 TGFB2
PDGFA COL4A4 PTHrP FGF1 COL5A1 FGF2 ENAH COL5A2 C4ST1 MSN COL1A1 FGFR1 GSN LAMC2 PDGFRB PDGFRB THBS2 COL1 KRAS CAV2 MRAS ARHGAP5 SOS2 PTEN AKT3 PDGFA PDGFC PGF ITGA2 PDGFRB RAP1B MAPK8 TGF[beta] MAPK signaling signaling Adipogenesis SMURF1 MAPK8 FOXO1A MAPK8 NGFB TRIB3 SKP1 PDGFRB PCK2 NEDD9 RASA2 EGR2 ETS1 SOS2 DDIT3 KLF11 KRAS GADD45A ATF3 MRAS GADD45B FOSB NF1 HIF1A SKIL RAP1B IRS1 SMURF1 DUSP1 MEF2D ZFYVE16 DDIT3 FAS HSPB1 SPOCK IL1A FAS TGFB2
MAP313 ZAK AKT3 MAP3K8 GADD45A Table 2: Genes involved in osteogenesis-related pathways that are downregulated in CYD-treated hMSCs.
was the most downregulated gene in the AIRmax line (40-fold), while CD69 was approximately 6-fold downregulated.
Bolar et al., "Loss-of-function mutations in TGFB2
cause a syndromic presentation of thoracic aortic aneurysm," Nature Genetics, vol.
Jiang, "miR-599 inhibits vascular smooth muscle cells proliferation and migration by targeting TGFB2
," PLoS ONE, vol.
Lidral et al (1997) evaluated the association of four candidate genes TGFA, TGFB2
, TGFB3, homeobox 7 (MSX1) variations in a population from Philippines; however, no evidence for association of TGFA with nonsyndromic CL/P was found in non-Caucasian population (35).
Moreover, genes upregulated in the MSC-[gamma] group were enriched for the TGF-[beta] receptor signaling pathway (annotation cluster 19, enrichment score 1.74, e.g., FMOD, CCL2, MAPK3K1, SMAD6, GDF15, and TGFB2
We have also verified Tgfb2
, Tle3, and Fbxl18 as novel chondrogenic targets regulated by the Sox trio.
NC caused by cysticerci localized in the subarachnoid base or intraventricular versus parenchymal Genes Log B Downregulated MTOR -0.69 0.95 NFKB2 -0.93 0.78 SLAMF1 -1.05 2.18 Upregulated IL12RB2 -0.81 1.19 IL24 0.82 0.96 TGFB2
1.06 2.13 The log fold change (Log FC) describes how much a quantity changes from an initial to a final value in a determinate gene.