TGFB1


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TGFB1

A gene on chromosome 19q13.1 that encodes a member of the transforming growth factor beta (TGFB) family of cytokines. These multifunctional peptides up- and downregulate proliferation, differentiation, adhesion, migration, death and other functions in many cell types. Active TGFB1 is either homodimeric or heterodimeric with other TGFB family members.

Molecular pathology
TGFB1 mutations cause Camurati-Engelmann disease; TGFB1 is often upregulated in tumour cells.
References in periodicals archive ?
B) The level of TGFB1 mRNA in the kidney quantified by qRT-PCR; values shown are the mean [+ or -] SE of 5 rats/treatment group.
Domain-specific mutations in TGFB1 result in Camurati-Engelmann disease.
TGFB1 mutations in four new families with Camurati-Engelmann disease: confirmation of independently arising LAP-domain-specific mutations.
These genes encoded pro- and antiinflammatory cytokines (IL10, IL18, TGFB1, IL6) and the gene encoding a suppressor of cytokine signaling (SOCS3), which is associated with intracellular TNF/IL-6 signaling.
We describe here a new, rapid, nonradioactive, and relatively inexpensive method for TGFB1 genotyping, using restriction site polymorphism (RSP) methodology.
Results for the AocI and MaeIII digestion for the 5'-end RSPs of the TGFB1 gene are shown in Fig.
In the future, clinical studies on the TGFB1 polymorphisms could confirm suspicions of the crucial role of TGF-[[beta].
005 superfamily, member 2) transforming growth factor, TGFB1 0.