TGFB1


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TGFB1

A gene on chromosome 19q13.1 that encodes a member of the transforming growth factor beta (TGFB) family of cytokines. These multifunctional peptides up- and downregulate proliferation, differentiation, adhesion, migration, death and other functions in many cell types. Active TGFB1 is either homodimeric or heterodimeric with other TGFB family members.

Molecular pathology
TGFB1 mutations cause Camurati-Engelmann disease; TGFB1 is often upregulated in tumour cells.
References in periodicals archive ?
Literature data on allele frequencies and genotypes of VEGFA and TGFB1 SNPs in chorionic tissue in miscarriage in the first trimester is absent.
TGFB1 genotype and three-year radiotherapy-induced toxicity data were available for 174 patients, 51 percent of whom had at least one copy of C-509T.
However, we observed no significant differences in TGFB1 and LAMA1 gene polymorphisms in patients with high myopia compared to healthy subjects.
Out of eight techniques, best keloid was produced by the technique where TGFB1 injection 1 was followed by ventral skin, ventral perichondrium, cartilage, and dorsal perichondrium punch excision, leaving behind only dorsal skin.
For TGFB1 protein, most of cancer tissue attained moderate to strong expression in the cytoplasm, but the protein was less intense in approximately one-fifth of patients and absent in three samples only.
CLA isomers have been found to act as PPAR ligands and shown to be involved in the inhibition of transcription of genes including TNF [37], NFKB1 [38], and NR1I3 [39] as well as transactivation: TGFB1 [40], BRCA1 [41], PTEN [42], p21/WAF1/CDKN1A [43], CEBPA [44], ABCB4 [45], and AOX [46].
These results were confirmed by qPCR analysis showing similar levels of expression of mRNAs implicated in fibrosis such as Tgfb1, Col1a1, and Col3a1 and of the tubular injury marker Kim1 (Figure 2(b)).
Of these, the upregulated genes were found to be HSPs, BAG3, SOCS3, GADD45G, GCLM, VLDLR, CYR61, DUSP1, DUSP5, FOS, EGR1, MAFB, NR4A1, PROP1, TGFB1, DNAJB1, ADM, and DDIT3.
Otros factores involucrados en la migracion de la CGP secretados por parte de las celulas somaticas vecinas, corresponden al factor 1 derivado del estroma (SDF1) y su receptor CXCR4 y al factor TGFb1 y su receptor ALK5 (Farini et al.) (Fig.
(2014) Transforming Growth Factor b1 (TGFb1) and Vascular Endothelial Growth Factor (VEGF) in the blood of healthy people and patients with Graves' orbitopathy--a new mechanism of glucocorticoids action?
PIGR (polymeric immunoglobulin receptor; Obara, et al, 2003), TRAC (Li, et al, 2009), FCAR (fc fragment of IgA, receptor; Tsuge, et al, 2001), HLA DRA (Akiyama, et al, 2002), IFNG (Masutani, et al, 2003), EDNI (Maixnerova, et al, 2007), FCGR 3B (Xu, et al, 2007), CD14 (monocyte differentiation antigen CD14; Yoon, et al, 2003), TNFa (tumour necrosis factor a; Tuglular, et al, 2003), TGFB1 (transforming growth factor b1, Lim et al, 2005), SELE (E-Eselectin gene; Takashi, et al, 2002), ACE (Draman, et al, 2008), AGT (Bantis, et al, 2004), VEGFA (Chow, et al, 2006) and MUC20 (Li, et al, 2006), are related to the predisposition and progression of IgAN (Hsu, et al, 2000).
A number of cytokines, including transforming growth factor [beta]-1 (TGFB1 gene product), may mediate fibrosis by stimulating COL1 synthesis and through other mechanisms.