TGFB1


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TGFB1

A gene on chromosome 19q13.1 that encodes a member of the transforming growth factor beta (TGFB) family of cytokines. These multifunctional peptides up- and downregulate proliferation, differentiation, adhesion, migration, death and other functions in many cell types. Active TGFB1 is either homodimeric or heterodimeric with other TGFB family members.

Molecular pathology
TGFB1 mutations cause Camurati-Engelmann disease; TGFB1 is often upregulated in tumour cells.
References in periodicals archive ?
It is formed in greater amounts in keloids and keloid fibroblasts react to lesser amounts of TGFB1 than non-keloid fibroblasts.
Best rabbit ear Keloid model can be produced by giving TGFB1 injection, followed by ventral skin, ventral perichondrium, cartilage, and dorsal perichondrium excision
The optimized conditions consisted of TGFB1 or COL1, 250 nM primers, and 250 nM probes, with 1 [micro]L cyclophilin.
To analyze the relationship between clinicopathologic features at the time of kidney biopsy, the expression levels of mRNA of COL1 and TGFB1 were evaluated by continuous analysis.
Domain-specific mutations in TGFB1 result in Camurati-Engelmann disease.
TGFB1 mutations in four new families with Camurati-Engelmann disease: confirmation of independently arising LAP-domain-specific mutations.
These genes encoded pro- and antiinflammatory cytokines (IL10, IL18, TGFB1, IL6) and the gene encoding a suppressor of cytokine signaling (SOCS3), which is associated with intracellular TNF/IL-6 signaling.
Seven TGFB1 polymorphisms recently have been reported as single-stranded conformational polymorphisms and applied to a multicenter study population, the Etude Cas-Temoin de L'Infarctus du Myocarde (ECTIM) study (3).
We describe here a new, rapid, nonradioactive, and relatively inexpensive method for TGFB1 genotyping, using restriction site polymorphism (RSP) methodology.
SERPINE1, ICAM1, F3, MMP3, CCL2, CXCL5, CXCL9, and VCAM1; and CD69, PLAU, PLAT, SELP, SELE, HLA-DRA, IL1 A, PLAUR, SAA1, TIMP2, CCL26, TGFB1, NR4A2, CSF1, and CXCL10: tissue remodeling during inflammation and angiogenesis
005 superfamily, member 2) transforming growth factor, TGFB1 0.
Relative mRNA expression of LCN2 (NGAL), KIM1, and TGFB1 were calculated by the comparative CT method ([2.