TGF-beta

TGF-beta

transforming growth factor beta; a growth factor synthesized by skeletal cells; found in most species.
References in periodicals archive ?
Cell growth of BG-1 ovarian cancer cells was promoted by 4-tert-octylphenol and 4-Nonylphenol via downregulation of TGF-beta receptor 2 and upregulation of c-myc.
NEW YORK, July 20, 2015 /PRNewswire/ -- The TGF-beta receptor signaling pathway activates the MAPK/SMAD signaling modules.
This project examines a newly hypothesized intrinsic repair mechanism in articular cartilage, mediated by the extracellular activation of large stores of latent (inactive) TGF-beta through the action of chondrocyte-secreted proteases.
The research by the Johns Hopkins Children's Center and the Johns Hopkins Institute of Genetic Medicine has found that aberrant signalling by a protein called transforming growth factor-beta, or TGF-beta, may be responsible for disrupting the way immune cells respond to common foods and environmental allergens, leading to a wide range of allergic disorders.
TGF-beta is well known for its widespread effects in the body, from controlling how cells in a various organs grow and develop to overseeing how they communicate with one another.
leucotomos to (a) directly inhibit MMP-1, 2, 3, and 9 activities, (b) inhibit MMP-2, and stimulate TIMPs, fibrillar collagens and TGF-beta in non-irradiated or ultraviolet (UV) radiated fibroblasts, and (c) inhibit MMPs and TGF-beta, and stimulate TIMPs in melanoma cells.
Researchers from IRB have discovered that metastatic cells have a survival advantage provoked by the TGF-beta gene, which has an elevated production by colorectal cancer cells, daily La Vanguardia quoted the leader of the project, Eduard Belle, as saying.
2002) Flexor tendon healing in vitro: effects of TGF-beta on tendon cell collagen production.
Balancing the activation state of the endothelium via two distinct TGF-beta type I receptors.
VEGF, which induces production of CTGF through pathways independent of TGF-beta, is upregulated along with an increase in myofibroblasts in fibrotic lesions in experimental models of pulmonary fibrosis.
Celgene also has entered into an exclusive worldwide license agreement with the Research Foundation of the State University of New York and the Toronto Hospital for Sick Children covering two ligase targets that mediate TGF-Beta signaling, for which patents have been filed.
TGF-beta is a regulatory protein that has multiple functions, including an early role in the inflammatory response to injury and a central role in triggering the chain of events leading to the induction of CTGF and scarring.