Activation of hepatic stellate cells by TGF alpha
and collagen type 1 is mediated by oxidative stress through c-myb expression.
Scientists sought to learn whether TGF alpha administered directly to the brain could help rats with stroke-induced loss of limb function, typically on one side - as is seen in humans.
When injected with with TGF alpha, the stroke-induced rats regained nearly all their motor function, while those rats that did not receive treatment improved just 30 percent.
In normal uterine endometrial cells, e strogen and estrogen/progesterone combinations inhibited cell proliferation and inhibited secretion of interstitial collagenase and growth factors [transforming growth factor (TGF) beta, and TGF alpha
but not epidermal growth factor (EGF)].
Methods are provided for inhibiting the differentiation of adipocyte precursor cells, and for treating or preventing obesity, which comprise administering an effective amount of a composition capable of binding to and activating the EGF receptor, preferably epidermal EGF or a functional derivative thereof, TGF Alpha
, an antibody specific for the EGF receptor or an anti-idiotypic antibody specific for an idiotope on an antibody specific for EGF.
KPI) today announced that the United States Patent and Trademark Office has issued to the company a notice of allowance for a patent application covering new compositions of matter consisting of TGF alpha modified with polyethylene glycol.
The company intends to use polyethylene glycol modified forms of TGF alpha in indications where the drug is to be administered systemically, such as in the treatment of gastrointestinal inflammation caused by cancer chemotherapy.
The issued patent will cover the use of certain therapeutic compounds, including the company's lead drug candidate, TGF alpha, for the prevention and treatment of gastrointestinal mucositis (GI mucositis), a painful and debilitating side effect often associated with the administration of cytotoxic or immune-suppressing therapies, such as cancer chemotherapeutic drugs.
Using animal models, we have shown that TGF alpha can limit intestinal damage caused by several commonly administered cancer drugs, including 5-fluorouracil and irinotecan," explained John M.
This new study follows positive results from a recently completed study conducted by NIH in collaboration with Kaleidos Pharma demonstrating that TGF alpha
increased both CD4 and CD8 T cell counts in SIV-infected monkeys.
This patent covers the use of certain cytokines, including TGF alpha
, in treating chronic wasting disease associated with cancer, AIDS and other diseases.
The Company's lead drug, TGF alpha
, is being studied in a non-human primate model of Parkinson's disease.