PPBP

(redirected from TGB1)

PPBP

A gene on chromosome 4q12-q13 that encodes a platelet-derived growth factor of the CXC chemokine family, which is a potent chemoattractant and activator of neutrophils. PPBP drives various cellular processes, including DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by synovial cells.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
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Hammond, "Efficiency of VIGS and gene expression in a novel bipartite potexvirus vector delivery system as a function of strength of TGB1 silencing suppression," Virology, vol.
Reinsel et al., "Pathogenicity of Alternanthera mosaic virus is affected by determinants in RNA-dependent RNA polymerase and by reduced efficacy of silencing suppression in a movement-competent TGB1," Journal of General Virology, vol.
Bae et al., "AltMV TGB1 nucleolar localization requires homologous interaction and correlates with cell wall localization associated with cell-to-cell movement," Plant Pathology, vol.