T gene

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T gene

A genes on chromosome 6q27 that encodes brachyury, an embryonic nuclear transcription factor that effects transcription of genes required for mesoderm formation and differentiation, and mediates epithelial-mesenchymal transition. It is localised to notochord-derived cells.

Molecular pathology
Brachyury is the definitive diagnostic marker of chordoma; it is overexpressed in various cancers and promotes invasion.
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