TFRC

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TFRC

A gene on chromosome 3q29 that encodes transferrin receptor, a protein required for development of erythrocytes and the nervous system.
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Two transferrin receptors, TfR1 and TfR2, sense the plasma iron that convey the information to the BMP receptor complex via the additional proteins HFE and haemojuvelin (HJV).2,7,16-18 BMP6 activates the intracellular S-mothers against decapentaplegic (SMAD) pathway, which in turn up-regulates the HAMP promoter to synthesise hepcidin.
Blood Tf binds to transferrin receptor 1 (TfR1) on endothelial cells lining blood capillaries and the binding complex is internalized into endosomes (Fig.
Iron is an important and essential part of numerous cellular metabolic activities and its homeostasis is regulated by a large set of cytokines (IL-1[beta] TNF-[alpha], IFN-[gamma], and IL-6, etc.) and iron-regulatory genes (ferroportin 1 (FPN-1), hemojuvelin (Hjv), hereditary hemochromatosis gene (HFE), divalent metal transporter 1 (DMT1), transferrin (Tf), Tf receptors 1 and 2 (TfR1, TfR2), natural resistance-associated macrophage protein-1 (Nramp-l), ceruloplasmin, and hephaestin (Heph)) while liver mainly manages body iron by making vivid changes in the expression of such genes (Camaschella, 2005; Ganz, 2006).
In summary, we investigated DMT1, FPN, HEPH, and TfR1 expression, as well as chronic disease activity markers in diabetic patients with and without IDA and controls, demonstrated that in diabetic iron-deficient patients, this protein expression depends primarily on body iron stores rather than being affected by chronic inflammation or diabetes per se.
Transferrin receptor 1 (TfR1)[sup][35] and bone morphogenetic protein 6 receptor (BMP-6R)[sup][29],[36] can sense transferrin saturation (TS) and tissue iron content, respectively, further regulating hepcidin concentration.
Concomitantly, recent study showed, that Hep suppressed the neural iron accumulation in rat by inhibiting the expression of Fe-transport proteins (TfR1, DMT1, Fpn1) under Fe-overload conditions (Du et al., 2015).
The following antibodies and reagents were used: [beta]-actin (Alpha Diagnostic International, USA), TfR1 (Sigma-Aldrich, USA), FPN1, DMT1 (+IRE) and DMT1 (-IRE) (Alpha Diagnostic International, USA), L-ferritin (Abcam Inc., SF, USA), cleaved PARP, caspase-3, phospho-p38 (p-p38) and p38 (Cell Signaling Technology, USA), Bcl-2 and Bax (Santa Cruz Biotechnology, USA), A[[beta].sub.25-35] peptide (Sigma-Aldrich, USA), and TUNEL in situ Cell Death Detection Kit (Roche Diagnostics GmbH, Mannheim, Germany).
This disease is caused by mutations in transferrin receptor 2 (TFR2) gene [2] that codes for two main isoforms, namely, Tfr2 alpha (Tfr2[alpha]) and Tfr2 beta (Tfr2[beta]), that show moderate homology to the type 1 transferrin receptor (Tfr1) [3].
E2-treated SKOV-3 showed slightly reduced intracellular labile iron content, reduced expression of hepcidin and significantly increased expression of TFR1 but not TFR2; FPN expression was overall similar to that of controls.
Transferrin is can bind two [Fe.sup.3+] ions with very high affinity and donate iron to cells throughout the body via transferrin receptor 1 (TfR1) (Kovac et al., 2009).
According to the companies, CD71, also known as transferrin receptor 1 (TfR1), is highly expressed in a number of solid and hematologic cancers and has attractive molecular properties for efficient delivery of cytotoxic payloads to tumor cells.
Este acoplamiento de las IRPs con los IREs forma el sistema conocido como IRE/IRP, con efecto en la traduccion de proteinas como la ferritina, el receptor 1 de transferrina (TfR1, por su nombre en ingles transferrin receptor protein 1) y la ferroportina (Fpn); pero a la vez esta regulacion, produce una modulacion entre las mismas proteinas dependiendo del grado de acoplamiento IRE/IRP.