A 1 [micro]L injection of adenovirus virus of GFP (1E + 11 PFU/mL) or TFEB
(1E + 11 PFU/mL) was delivered unilaterally to the left substantia nigra pars compacta at a rate of 0.15 [micro]L/min.
TFE3 is a member of the microphthalmia (MiT) family of transcription factors, which includes MiTF, TFEB
, TFEC, and TFE3, all of which share a common structure consisting of a helix-loop-helix leucine zipper dimerization motif, a transactivation domain, and a basic region involved in DNA binding.
Transcription factor EB (TFEB
) is one of the regulators of autophagy.
The TRCC group of rare renal neoplasms predominately arises in pediatric patients with chromosomal translocation involving the TFE3 transcription factor gene located at 11p11.2 locus or the TFEB
gene at 6p21.
The only other renal cell neoplasm positive for melanocytic markers, usually nonreactive with pancytokeratin and EMA, and variably reactive with PAX8 (~50%), is TFEB
[t(6;11)] microphthalmia transcription factor translocation carcinoma.
(42) Another renal translocation carcinoma exhibits the t(6;11)(p21;q12) translocation with a gene fusion between the alpha gene and the transcription factor EB (TFEB
(106) In the past 10 years, numerous studies (67,106,107) have validated the fact that renal cell carcinomas with translocations involving the TFE3 gene located at the Xp11.2 locus or the TFEB
gene located at the 6p21 locus are a unique--albeit relatively rare--group of renal malignancies.
The MiTF family of transcription factors includes MiTF, TFE3, TFEB
, and TFEC.
(42,43) Similarly, TFEB
is also a transcription factor that is overexpressed in pediatric RCCs with t(6; 11)(p21; q12).
TFE3 belongs to the same family of transcription factors as MiTF, TFEB
(24) Other members of this family include transcription factor EB (TFEB
), transcription factor EC (TFEC), and MITF.
The transcription factor binding to IGHM enhancer 3 (TFE3) protein belongs to a family of basic helix-loop-helix/leucine zipper transcription factors that also includes transcription factor EB (TFEB
), transcription factor EC, and microphthalmia-associated transcription factor.