TFAP4

A gene on chromosome 16p13 that encodes a transcription factor of the basic helix-loop-helix-zipper (bHLH-ZIP) family, which binds and oligomerises DNA; it activates cellular and viral genes by binding to the symmetrical DNA sequence CAGCTG.

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As revealed by the RI parameter, TFs with the lowest values have a high out-degree, but at the same time, they present a high in-degree, such is the case of ZHX2, ADNP, SMAD6, POU3F1, GTF2A1, ZIC2, POU6F1, TFAP4, ARID5B, or RUNX1.

In- Out- transcript Gene degree degree RI count RUNX1 155 556 0.517749925 9382.91 ARID5B 114 392 0.49206167 12.885 TFAP4 190 632 0.483369442 642.65 POU6F1 87 268 0.442040072 229.68 ZIC2 135 407 0.438502347 10132.46 GTF2A1 100 253 0.357562642 1219.94 POU3F1 80 198 0.331108025 4.585 SMAD6 175 408 0.289214257 2936.75 ADNP 132 292 0.256880007 651.685 Table 3: The top 5 highest and lowest values of TFs in the RegulonDB E.

The Transcriptional Network Structure of a Myeloid Cell: A Computational Approach

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