TFAP2A

TFAP2A

A gene on chromosome 6p24 that encodes a member of the AP-2 family of transcription factors, which activate the transcription of genes involved in proper eye, face, body wall, limb and neural tube development. TFAP2A inhibits C/EBP alpha, MCAM/MUC18 and MYC.

Molecular pathology
TFAP2A mutations cause branchiooculofacial syndrome.
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References in periodicals archive ?
Furthermore, tfap2a is believed to modulate the activity of fibroblast growth factor and notch by activating the inhibitor bmp7a, while playing a key role in neural development as well (20).
Tfap2a promotes specification and maturation of neurons in the inner ear through modulation of Bmp, Fgf and notch signaling.
Genes like NRF1, SPIB, GABPA, or TFAP2A present a high RI since they do not have regulators within the database.
In the first case, we have for instance NFYA, NFYB, and NFYC; whereas in the latter case, we have TFAP2A, TFAP2C, and MAZ.
The mRNA levels for neural crest markers (TFAP2A, CD271, Sox10, Pax3, and nestin) were also downregulated immediately upon MSC induction (Figure 3(b)).
Based on the JASPAR database for predicting transcription factor binding, we found that the G allele of rs3731795 might increase the binding of transcription factors, such as TCF3, TFAP2A, and TCF4, to the promoter of miR-10b, compared to the C allele (Table 4).
TFAP2A (AP-2) Cytoplasmic expression of AP--2 is reduced in prostate cancer cells (63).
The TFBS motifs transcription factor AP-2 alpha (TFAP2A), myeloid zinc finger 1 (MZF1), and specificity protein 1 (SP1) were identified as significantly enriched within the WNT pathway dataset compared to the background gene set with P values estimated at 6.83 x [10.sup.-29], 1.34 x [10.sup.-11], and 3.01 x [10.sup.-6], respectively and are represented as probability sequence motifs (Figure 3).
It has been demonstrated using the online AliBaba2.1 (http://www.gene-regulation.com/pub/programs/alibaba2/index.html) program that this SNP (in the context of the C allele) was associated with lack of transcription factor binding sites and that the G allele was associated with transcription factor binding sites for C/EBPalpha (also known as CCAAT/enhancer-binding protein alpha), AP-2alpha (also known as TFAP2A), and Sp1.
Immunofluorescence analysis showed a homogeneous expression of the specific NC markers AP2 [transcription factor AP-2 alpha (TFAP2A)] and SOX9 [SRY (sex determining region Y)-box 9] (data not shown) and HNK1 and p75, as well as the absence of the neuroepithelial marker PAX6 (paired box 6) (Figure 1B).
lockjaw encodes a zebrafish tfap2a required for early neural crest development.
We added 11 markers [GATA3, GATA binding protein 3; GDNF, glial cell derived neurotrophic factor; OPCML, opioid binding protein/cell adhesion molecule-like; PENK, proenkephalin; TFAP2A, transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha); APP, amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease); CACNA1G, calcium channel, voltage-dependent, T type, alpha 1G subunit; HOXA1, homeobox A1; NEUROG1, neurogenin 1; APBA2, amyloid beta (A4) precursor protein-binding, family A, member 2; and TRRAP, transformation/transcription domain-associated protein on the basis of a study that indicated increased methylated DNA in CRC tissue (19).