TERT


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TERT

A gene on chromosome 5p15.33 that encodes telomerase reverse transcriptase, which, with TERC (an internal telomerase RNA template), comprises the telomerase holoenzyme complex.
References in periodicals archive ?
To date, rare genetic variants in multiple genes have been discovered in familial IPF, which mainly be subdivided into two categories as follows: genes related to surfactant protein metabolism and genes that maintain telomere length.[6] Germline defects in telomere maintenance are common in IPF, several genes in the telomere maintenance pathway have been implicated in IPF families, including those that affect telomerase catalytic activity ( TERT, TERC ), telomere biogenesis ( DKC1, PARN, NAF1 ) or telomere end regulation ( TINF2, RTEL1 ).
A serial dilution analysis of the 7-deaza-dGTP--containing assays was performed for both the C228T and C250T ddPCR assays with use of DNA from cell lines with known TERT promoter mutation status.
Each group of serum-starved, Ang II-induced, or DMSO or AT1R blocker (TERT) plus Ang II-induced EPCs was coplated in 100 [micro]l of various conditioning media: plain EGM-2, EGM-2 with 100 [micro]M (-)-isoproterenol hydrochloride (ISO; Sigma-Aldrich), or EGM-2 with 100 nM formoterol fumarate dihydrate (Formo; Sigma-Aldrich).
Therefore, we herein report for the first time a novel role of Par-4 interaction with TERT, followed by nuclear translocation to induce islet [beta] cell apoptosis, and we reveal the relationship between Par-4 and Akt signalling in the apoptosis of islet [beta] cells in type 2 diabetes.
It is claimed that TERT complexes are dynamic and thus there are at least two different forms of TERT complexes.
Liu et al., "TERT promoter mutations and their association with BRAF V600E mutation and aggressive clinicopathological characteristics of thyroid cancer," Journal of Clinical Endocrinology and Metabolism, vol.
Based on these observations it was established that telomerase has at least one non-canonical and elongation-inde- pendent function.11 Certain studies involving mouse models for two stage tumorigensis showed that TERT over expression promoted papilloma formation.8 There was also wide spread speculation that mice deficient in telomerase and having short telomeres were resis- tant to tumorigensis.
The results showed evidence of TERT expression and telomerase activity in 21 of the 42 tumours, regardless of M918T RET mutation.
countries Armenia is forming systematized relations, news agency TERT.AM of
The researchers used x-ray crystallography, a technique that analyzes the diffraction patterns of x-rays beamed at crystals of a molecule, to determine the three-dimensional structure of the enzyme's active region--a catalytic component called telomerase reverse transcriptase protein (TERT).
The studied genes included telomerase (TERT), telomerase-associated protein (TEP1), telomeric repeat binding factor 1 (TRF1), telomeric repeat binding factor 2 (TRF2) and protection of telomeres 1 (POT1).
The protein, known as TERT, is a key component of telomerase, an enzyme that adds DNA to the tips of chromosomes and helps cells proliferate.