TERT


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TERT

A gene on chromosome 5p15.33 that encodes telomerase reverse transcriptase, which, with TERC (an internal telomerase RNA template), comprises the telomerase holoenzyme complex.
References in periodicals archive ?
We describe the development and analytical validation of a real-time RT-PCR assay for the absolute quantification of TERT splice variants [alpha]+[beta]+, [alpha]-[beta]+, [alpha]+[beta]- and [alpha]-[beta]-, a method for quantifying the expression of each individual TERT splice variant in 6 tumor cell lines.
In this study, Artandi and his colleagues purified the TERT protein from cultured human cells and found that it was associated with a chromatin-remodeling protein implicated in the Wnt pathway.
We are pleased to see promising results in animal trials with our optimized TERT vaccine for dogs," said Dr.
TERC and TERT mutations (5%-10% each of all cases) are found in autosomal dominant and recessive DC and show disease anticipation, such that successive generations not only inherit the genetic lesion but also have shorter telomeres, which may produce an earlier onset of clinical manifestations (8).
Structure of the Tribolium castaneum telomerase catalytic subunit TERT.
Manipulating TERT could open up new avenues for developing therapies, suggest the researchers, led by Dr Steven Artandi, from Stanford University in California.
We were surprised and pleased that modified TERT mRNA worked, because TERT is highly regulated and must bind to another component of telomerase," said Ramunas.
The authors of the study have also identified TERT as the gene susceptible to breast and ovarian cancer.
The cell lines of the present invention can be obtained by integrating both a nucleotide sequence encoding tamoxifen-induced Cre recombinase and a nucleotide sequence encoding insulin regulated by glucose-sensitive promoter into the chromosome in a human immortalized hepatic cell line FERM BP-7498 containing the TERT gene inserted in between a pair of LoxP sequences.
They taught dendritic cells to make a part of the telomerase protein called TERT and display it on their surfaces.
Contractor name : ACORD-CADRU INCHEIAT CU 3 OPERATORI ECONOMICI CASTIGATORI: LOCUL 1) SC TELOR INVEST SRL CU TERT SUSTINATOR SC TEHNOLOGICA RADION SRL SI SUBCONTRACTANTI SC TEHNOLOGICA RADION SRL SC TELOXIM CON SRL;
More than 60 percent of the tumors had mutations in the BRAF oncogene, the PTEN tumor suppressor gene or the promoter region of a gene called TERT.