TERT


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TERT

A gene on chromosome 5p15.33 that encodes telomerase reverse transcriptase, which, with TERC (an internal telomerase RNA template), comprises the telomerase holoenzyme complex.
References in periodicals archive ?
It is claimed that TERT complexes are dynamic and thus there are at least two different forms of TERT complexes.
TERT promoter mutations in primary and secondary glioblastomas.
Parkinson namely HaCaT TERT HaCaT TERT-HA HaCaT PURO) SCC-25 cells HEK-125 cells HEK 127 cells and N-HEK cells.
TERC and TERT gene mutations in patients with bone marrow failure and significance of telomere length measurements.
suggest new strategies for manipulating TERT for therapeutic purposes in treating disorders associated with tissue injury and ageing.
A vaccine containing dendritic cells displaying TERT was found to stimulate an immune response that slowed the growth of skin, breast and bladder cancers implanted into mice.
TERT has been shown to contain at least 6 alternative splicing sites (16-20); however, only the full-length TERT transcript is associated with telomerase activity (16-18).
A good correlation between TERT expression and telomerase activity, however, has been reported (11).
Based on the foregoing, TERT is an antigen or tumor marker expressed in both differentiated and progenitor cancer cells making vaccination against TERT a potentially effective measure to induce an immune response against cancer cells at both stages of differentiation.
They had discovered that overexpressing TERT in the skin of mice stimulated formerly resting adult stem cells to divide--even in the absence of other telomerase components.
Contractor name : ACORD-CADRU INCHEIAT CU 3 OPERATORI ECONOMICI: LOCUL 1) SC VIAROM CONSTRUCT SA; LOCUL 2) SC AKTIS ATE SA; LOCUL 3) SC OMEGA EDILITARE SRL, CU TERT SUSTINATOR SC GLACIAL PROD SRL