TCF7L2


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TCF7L2

A gene on chromosome 10q25.3 that encodes a high mobility group (HMG)-box-containing transcription factor, which plays a key role in Wnt-signalling pathway, glucose homeostasis and key developmental and growth regulatory mechanisms of cells.

Molecular pathology
TCF7L2 mutation increases the risk of type-2 diabetes.
References in periodicals archive ?
The DNA sequences for TCF7L2 and HNFifi were taken from the genome browsers, National Centre for Biotechnology Information (NCBI), version 36 (http://wwwncbi.
13 Additionally, in two recent related studies for Pakistani population it was reported that SNPs in or near PPARG, TCF7L2, FTO, CDKN2A/2B, and KCNQ1 may have potential associations with T2DM, with similar effect sizes to those seen in European populations.
En el tercero y el cuarto estudios se exploraron variantes en mas de 14 genes, revelando que los SNP en TCF7L2 y ADRB correlacionan con el riesgo para la diabetes (16-17).
Extensive study into the genetic profile of colorectal adenocarcinoma by TCGA identified the 8 most frequently mutated genes (APC, TP53, KRAS, PIK3CA, FBXW7, SMAD4, TCF7L2, and NRAS) (7); mutations in all of these genes (except for TCF7L2) were also identified in our rectal adenocarcinoma-based study.
A 2007 study identified the genes PPARG, KCNJ11, and TCF7L2 as established genes associated with common forms of type 2 diabetes.
Impact of nine common type 2 diabetes risk polymorphisms in Asian Indian Sikhs: PPARG2 (Pro12Ala), IGF2BP2, TCF7L2 and FTO variants confer a significant risk.
CT or TT genotype of rs7903146 polymorphism in TCF7L2 exhibited a higher prevalence and severity of CAD [37]; and the T allele of rs5065 polymorphism in ANP showed a decreased severity of CAD in an Iranian population [38].
El tercer estudio, llevado a cabo en probandos de la Ciudad de Mexico, con variantes en 14 genes candidato para sindrome metabolico, mostro que las variantes en TCF7L2 estaban fuertemente correlacionadas con la DM2 y otro nuevo marcador asociado; el SNP rs4994 del gen ADRB3 (38).
In Hong Kong Chinese, type 2 diabetes-related genetic variants of HHEX , TCF7L2, and CDKAL1 have also been reported to be associated with increased all-site cancer although the underlying mechanism remains to be explored.
TCF7L2 rs7903146 and rs12255372 gene polymorphisms which predispose individuals to T2DM development are associated with diminished therapeutic response to SU.
Associations between TCF7L2 polymorphisms and risk of breast cancer among Hispanic and non-Hispanic White women: The Breast Cancer Health Disparities Study.