TCF7L2


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TCF7L2

A gene on chromosome 10q25.3 that encodes a high mobility group (HMG)-box-containing transcription factor, which plays a key role in Wnt-signalling pathway, glucose homeostasis and key developmental and growth regulatory mechanisms of cells.

Molecular pathology
TCF7L2 mutation increases the risk of type-2 diabetes.
References in periodicals archive ?
[121 The genes identified in [greater than or equal to] 2 independent populations include transcription factor 7-like 2 (TCF7L2), adiponectin (ADIPOQ), melatonin-receptor 1B gene (MTNR1B), glucokinase (GCK), glucokinase regulator (GCKR), fat mass and obesity-associated (FTO), insulin-receptor substrate 1 (IRS1) and potassium voltage-gated channel subfamily Q member 1 (KCNQ).
Sethi, "Tumour necrosis factor-a inhibits adipogenesis via a [beta]-catenin/ TCF4(TCF7L2)-dependent pathway," Cell Death & Differentiation, vol.
[25] postulated that predicted binding motifs for CD86 rs2715267 are SRF, ELF3, TCF3, TCF7, TCF7L2, and ZFP105, but these speculations were not confirmed by any in vitro study.
Chen et al., "Effect of miR-212 targeting TCF7L2 on the proliferation and metastasis of cervical cancer," European Review for Medical and Pharmacological Sciences, vol.
In the pancreas and hepatocytes, [beta] catenin/Wnt signalling pathways activate glucokinase promoter activities in the presence of PPAR-[gamma] and cyclin-D promoter with transcription factor 7-like 2 (TCF7L2) binding sites [68] and play an important role in maintaining [beta]-cell function [69].
Another article reported that a TCF7L2 missense variant rs138649767 associates with colorectal cancer risk by interacting with a GWAS-identified regulatory variant rs698326 in the MYC enhancer [91].
The DNA sequences for TCF7L2 and HNFifi were taken from the genome browsers, National Centre for Biotechnology Information (NCBI), version 36 (http://wwwncbi.nlm.nih.gov), and Ensemble, version 54 (http://wwwensemble.org/index.html).
Wnt signaling and TCF7L2 are negative regulators of hepatic gluconeogenesis, and TCF7L2 belongs to the downstream effectors of insulin in hepatocytes [101].
Finally, in a prospective epidemiological study from the EPIC-InterAct cohort, including 8086 incident T2D cases in 11,035 participants over 12.5 years, habitual coffee consumption was associated with a 7% T2D risk reduction among carriers of the diabetes increasing risk allele at transcription factor 7-like 2 locus (TCF7L2) [76].
Moreover, silencing of the T-cell factor 7-like 2 (TCF7L2) (an important transcription factor of the Wnt/[beta]-catenin signaling pathway) gene increased the apoptosis of pancreatic
A moderately significant association of 'C' allele with insulin levels, HbA1c, insulin resistance and fasting glucose levels was observed in our study similar to a previous report.13 Additionally, in two recent related studies for Pakistani population it was reported that SNPs in or near PPARG, TCF7L2, FTO, CDKN2A/2B, and KCNQ1 may have potential associations with T2DM, with similar effect sizes to those seen in European populations.6,24 Though, this is an exciting finding further research is required to establish an affirmative causal link.