TCF7L2


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TCF7L2

A gene on chromosome 10q25.3 that encodes a high mobility group (HMG)-box-containing transcription factor, which plays a key role in Wnt-signalling pathway, glucose homeostasis and key developmental and growth regulatory mechanisms of cells.

Molecular pathology
TCF7L2 mutation increases the risk of type-2 diabetes.
References in periodicals archive ?
The TCF7L2 gene has previously been strongly linked to type 2 diabetes but not heart and artery disease.
The Mediterranean diet has long been known to reduce these risks, but it has not been discovered until now that this holds true even in people at risk of developing diabetes or heart complications as conferred by variants in the TCF7L2 gene they carry.
One of the sequence variants detected by NutraGene's type 2 diabetes genetic test is a single nucleotide polymorphism (a single base variation in the sequence of the DNA) in the TCF7L2 gene on chromosome 10.
Most recently, an analysis of more than 5,500 pregnant women participating in the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study demonstrated that a common maternal variant of the TCF7L2 gene is associated with a higher risk of gestational diabetes, as defined by the new International Association of Diabetes and Pregnancy Study Groups and thus a higher risk of adverse pregnancy outcomes, he told meeting participants.
Indeed, the rs12255372 and rs7903146 polymorphisms of the TCF7L2 gene are now being proposed for routine genotyping of a population to identify T2DM subjects (14).
Data from TCF7L2 knockout mice and cultured cell studies indicate a range of potential functions that include effects on glucagon-like peptide 1 (GLP1) signaling in [beta]-cells, proliferation of [beta]-cells, and insulin secretion.
The current finding builds on Grant's 2006 discovery, now widely replicated, that a gene called TCF7L2 is strongly linked to type 2 diabetes.
The TCF7L2 gene carries the code for a transcription factor--also called TCF7L2--a protein that binds to genes and regulates their activity.
TCF7L2 is a genetic defect associated with an increased risk of developing Type 2 diabetes.
Certain alleles of three genes--PPARG, TCF7L2, and KCNJ11--increased the risk of developing type 2 diabetes.
Three genes--PPARG, TCF7L2, and KCNJ11--contained alleles that increased the risk of type 2 diabetes development.