In the hypothalamus of 45-day-old cockerels, 246 overexpressed genes were related to neurogenesis (MAPK9, HNC1, APOD, TCF7
, POU3F1, GBX1, and KNCNQ2), neurological signal transmission (RIMS4, SV2C, CNTNAP2, GRM5, MAGI2, SV2B, CYSLTR1, SLC5A7, and CHRNB3), and neurotransmitter secretion (SYTL5, WNT7, SLC1A, SYN3, GAD1, SYNJ1, SYT9, SCL5A7, OTOF, and RAB3C) (see Figure S2, goo.gl/tC9GTZ).
 postulated that predicted binding motifs for CD86 rs2715267 are SRF, ELF3, TCF3, TCF7
, TCF7L2, and ZFP105, but these speculations were not confirmed by any in vitro study.
Only Lef1, Tcf7
, and Prkg2 were found in both gene sets (Supplementary Figure 3a).
Schulz et al., "Tcf7
is an important regulator of the switch of self-renewal and differentiation in a multipotential hematopoietic cell line," PLoS Genetics, vol.
Of the PLC samples, we found that the transcriptional expressions of MLH3, ACSL6, CD55, CR1, PDE3B, CCNB1, PAICS, SEC62, BIRC3, TCF7, NT5E, and PSPH in the PBMCs of gan-shen Yin deficiency group were significantly lower than those in non-gan-shen Yin deficiency group (Figure 1(a), p < 0.05).
According to our study's findings, 17 mRNAs (MLH3, ACSL6, CD55, CR1, XRCC4, CTSK, KRAS, DDE3B, CCNB1, PAICS, SEC62, PSMD6, BIRC3, TCF7, NT6E, PSPH, and TRCP1) in PBMC of PLC patients with gan-shen Yin deficiency were different from those in PLC patients without gan-shen Yin deficiency .
The fold change in the top 5 of the downregulated genes (Kitl, Pparg, Vegfc, Ptgs2, and Pdgfb) ranged from 24.57 to 5.95 and in the top 5 of the upregulated genes (Mmp2, Dapk2, Tcf7
, Wnt1, and Birc3) from 6.91 to 3.18.
Similarly, in patients with SLE, an aberrant expression of Wnt/[beta]-catenin signaling related genes HIG2, TCF7
, KHSRP, WWP1, SMAD3, TLK2, AES, CCNI, and PIM2 was observed in the peripheral blood [CD.sup.4+] T cells in patients with SLE [18, 28].
The risk for non-HLA loci appears to be lower in individuals carrying high-risk HLA genotypes, as has been seen with PTPN22 (rs2476601) [21,29] and TCF7 (rs5742913) [30,31].
Lazzeroniet al., "Apolymorphism in the TCF7 gene, C883A, is associated with type 1 diabetes," Diabetes, vol.