TCF4

TCF4

A gene on chromosome 18q21.1 that encodes a basic helix-loop-helix (bHLH) transcription factor, which recognises an Ephrussi-box (E-box)-binding site first identified in immunoglobulin enhancers and expressed predominantly in pre-B-cells.

Molecular pathology
TCF4 mutations cause Pitt-Hopkins syndrome.
References in periodicals archive ?
Expression of Wnt pathway target genes was detected, including Myc, TCF4, and CCND1, which were all inhibited after regulating LINC00261 (Figure 6C).
73] In addition, high levels of MALAT1 have been reported in endometrioid endometrial cancer,[58] in relation with aberrant activation of the Wnt/beta-catenin pathway where the Wnt-effector transcription factor TCF4 interacts with the MALAT1 promoter region.
2008) demonstrated prominent hypermethylation of CpG dinucleotides in TCF4 exon 1, which significantly correlates with gene inactivation in early stage gastric cancers and in intestinal-type gastric cancers.
Nateri AS, Spencer-Dene B, Behrens A (2005) Interaction of phosphorylated c-Jun with TCF4 regulates intestinal cancer development.
2007: Haploinsufficiency of TCF4 causes syndromal mental retardation with intermittent hyperventilation (Pitt-Hopkins syndrome).
2013) and alter the physical interactions of c-Myc by affecting binding of transcription factor 7-like 2 (TCF7L2) and TCF4 (Pomerantz et al.
Table 5 Current estimate (IPCA coupon) of theoretical cash flows Current estimate (R$ million) TCF1 TCF2 TCF3 TCF4 Reference date 1 - 06/29/2012 756.
AS-like phenotypes have also been described with mutations in SLC9A6 [solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6], TCF4 (transcription factor 4), and MECP2 (methyl CpG binding protein 2) (9, 10).
One specific laboratory experiment currently underway at VCU to better understand the function of one of these genes, TCF4, is being led by Joseph McClay, Ph.
3 Post-transcriptional regulation of messenger RNAs; neuron maturation, adult neurogenesis MTHFR Methylenetetrahydrofolate 1p36,3 Key enzyme in folate reductase metabolism TCF4 Transcription factor 4 18q21.
To test this, the researchers delivered a TCF4 molecule in utero that forced the Cux2-positive RGCs to prematurely differentiate.
One of the involved genes, TCF4, is involved in arginine metabolism and is essential for normal brain development.