Sheng, "MicroRNA-138 is a potential biomarker and tumor suppressor in human cervical carcinoma by reversely correlated with TCF3
gene," Gynecologic Oncology, vol.
Some key genes such as hydrogen sulfide, chromobox 5 (CBX5), and transcription factor 3 (TCF3
) are related to PD [6, 7].
Studies on murine hair follicles have also revealed expression of, inter alia, CK19 [8, 22] and numerous transcription factors, that is, Sox9, Lgr5, Gli1, Hopx, LHX2, Nfatc1, and Tcf3
FISH analysis using dual color probes for the PBX1 gene at 1q23.3 and TCF3
gene at 19p13.3 detected three copies of 1q in 32% of bone marrow cells.
When leukaemia cells from 279 patients with pre-beta-cell ALL were analyzed, 209 had inactivating lesions in genes encoding beta-cell transcription factors) PAX-5; IK2F1; EBF1 and TCF3
Further study showed Id genes enable heart formation by turning down the Tcf3
and Foxa2 proteins, which inhibit the process, and turning up Evx1, Grrp1 and Mesp1, which support the process.
Bar-Ziv et al., "Control of breast cancer growth and initiation by the stem cell-associated transcription factor TCF3
," Cancer Research, vol.
Based on the JASPAR database for predicting transcription factor binding, we found that the G allele of rs3731795 might increase the binding of transcription factors, such as TCF3
, TFAP2A, and TCF4, to the promoter of miR-10b, compared to the C allele (Table 4).
Interestingly, Law et al (28) revealed that [beta]-catenin could be phosphorylated by PKA which leads to its interaction with both SF1 and TCF3
localized in the promoter of Lhcgr gene and activation of this gene (28).
One example is the very aggressive and incurable subtype associated with a t(17;19) chromosomal translocation, which occurs due to breakage and aberrant fusion of genetic material in the tumour cells, resulting in the formation of a new oncogenic protein encoded by the genes TCF3
and HLF (TCF3-HLF-positive leukemia cells).
In addition, [beta]-Catenin inactivates transcription factor 3 (Tcf3
), which inhibits Oct3/4, Sox2, and Nanog and interacts with Oct4 thereby increasing its activity.