ADTKD is also caused by mutations in the TCF2
gene encoding hepatocyte nuclear factor 1 beta (4).
Nonsense and missense mutations in the human hepatocyte nuclear factor 1 beta gene (TCF2
) and their relation to type 2 diabetes in Japanese.
Mutations of the WNT4 and TCF2
genes have recently been found associated with MRKH syndrome (4,14).
Li, "Genetic variants in MMP9 and TCF2
contribute to susceptibility to lung cancer," Chinese Journal of Cancer Research, vol.
Species Primer Primer sequence name Nezara viridula NvF1 TGA ACT AGG ACA ACC CGG A NvR2 GAA GGG TCA AAG AAT GAT GT Euschistus servus EsF1 GAA CTA GGA CAA CCA GGA EsR1 CGG TCA GTT AAT AGT ATG GTG A Chinavia hilaris ChF2 ATG TAG TAG TTA CCG CTC AC ChR2 AAT CGG ATC TCC TCC TCC TGA T Euschistus quadrator EqF2 CGT AGT TGT AAC CGC CCA TGC A EqR1 TTC CGG TCA GTT AAT AGT Euschistus tristigmus EtF2 TGT TGT AGT TAC TGC TCA CGC A EtR1 GTA TTA AAG CGA TCG Piezodorus guildinii PgF1 GAA TTA GGT CAA CCT G PgR1 CTA TTA AAG TTG CGG TCT G Thyanta custator custator TcF2
ATG TAG TAG TTA CAG CAC AT TcR2 AAT AGG ATC TCC CCC TGA A Species GenBank Accession Nos.
Implication of genetic variants near SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, FTO, TCF2
, KCNQ1, and WFS1 in type 2 diabetes in a Chinese population.
HNF1B: Research on this MODY (maturity onset diabetes of the young) gene has produced a conclusive association of an intronic SNP (rs757210) in hepatocyte nuclear factor 1b (HNF1B) (previously known as TCF2
) with type 2 diabetes.
Ayrica baska genlerde (IPF1, PTF1A, FOXP3, GLIS3, TCF2
, EIF2AK3) mutasyonlar da yenidogan diyabetini de iceren coklu-sistem hastaliklarina yol acabilir (1-3,5,10).
Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2
protects against type 2 diabetes.
Renal phenotypes related to hepatocyte nuclear factor-1 3 (TCF2
) mutations in a pediatric cohort.
A significant fraction of prenatally detected, neonatal, and pediatric renal structural abnormalities are caused by complete or partial deletions of the TCF2
gene (also called HNF1B), which can also cause maturityonset (or MODY5) diabetes.