The concentration of slincR morpholino used was demonstrated to produce no visible morphological effects and to knockdown slincR expression at ~98% and ~80% upon exposure to 0.1% DMSO or 1 ng/mL TCDD
, respectively (Garcia et al.
Khazna is now seeking to qualify for Uptime Institute's Tier Certification of Constructed Facility (TCCF), for which TCDD
are considered a prerequisite requirement.
To determine whether AHR affects GR-mediated transcription or vice versa, ARPE-19 cells were cultured in DMEM/F-12 media, they were treated with TCDD
and Dex alone or in combination, and then mRNA expression of AHR target genes (CYP1A1, CYP1A2, and AHRR) (Figure 1(a)) and GR target genes (ANGPTL4, FKBP5, and GILZ) (Figure 1(b)) were analyzed by quantitative real-time PCR.
"In view of known immune-modulating effects of TCDD
, our finding of an increased prevalence of Graves' disease in Vietnam veterans potentially exposed to TCDD
warrants further investigation," Dr.
Exposure of dechorionated zebrafish embryos to TCDD
dissolved in embryo rearing solution resulted in dose-dependent mortality.
At the end of the experiment, two mice (from the LFD subgroups) displayed abnormalities (ex: immobility, tremors) and were excluded from the analyses [final group sizes: LFD-fed mice (LF-ctrl, n = 13); LFD-fed mice exposed to TCDD
(LF-tcdd, n = 15); HFD-fed mice (HF-ctrl, n = 14); and HFD-fed mice exposed to TCDD
, (HF-tcdd, n = 16)].
In 2013, the Ankara Public Prosecutor's Office kicked off an investigation into the tenders of high-speed train projects and began an investigation into the tenders conducted by two TCDD
regional directorates between 2009 and 2014.
The 250-km new line will be put into service later this month, TCDD
Given the documented adverse effects on the adult rat reproductive tract after a single in utero exposure to TCDD
, developmental exposure and differences in the half-life of TCDD
could have important consequences for the relevance of results from animal studies for human health.
In the men with highest TCDD
exposure, only 38 percent of their subsequent children were boys.
A study of mice exposed to TCDD
as adults demonstrated that AHR activation had adverse effects on long-term self-renewal (Sakai et al.
yZMyR (CyHAN)- Prosecutor Ali Ecelik, who was investigating the tender-rigging probe into Turkish State Railways (TCDD
) yzmir Port, was removed from his post and assigned to another city by the government on Friday.