TCDD

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TCDD

C₁₂H₄Cl₄O₂, a teratogenetic and carcinogenic dioxin, formerly used as an herbicide and also being a contaminant in Agent Orange. Synonym: 2,3,7,8-tetrachlorodibenzo-p-dioxin See: dioxin

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The concentration of slincR morpholino used was demonstrated to produce no visible morphological effects and to knockdown slincR expression at ~98% and ~80% upon exposure to 0.1% DMSO or 1 ng/mL TCDD, respectively (Garcia et al.

Signaling Events Downstream of AHR Activation That Contribute to Toxic Responses: The Functional Role of an AHR-Dependent Long Noncoding RNA (slincR) Using the Zebrafish Model

Khazna is now seeking to qualify for Uptime Institute's Tier Certification of Constructed Facility (TCCF), for which TCDD are considered a prerequisite requirement.

Khazna wins Uptime Institute's design certification

To determine whether AHR affects GR-mediated transcription or vice versa, ARPE-19 cells were cultured in DMEM/F-12 media, they were treated with TCDD and Dex alone or in combination, and then mRNA expression of AHR target genes (CYP1A1, CYP1A2, and AHRR) (Figure 1(a)) and GR target genes (ANGPTL4, FKBP5, and GILZ) (Figure 1(b)) were analyzed by quantitative real-time PCR.

Crosstalk between Aryl Hydrocarbon Receptor and Glucocorticoid Receptor in Human Retinal Pigment Epithelial Cells

"In view of known immune-modulating effects of TCDD, our finding of an increased prevalence of Graves' disease in Vietnam veterans potentially exposed to TCDD warrants further investigation," Dr.

Agent Orange exposure increases risk of graves' disease

Exposure of dechorionated zebrafish embryos to TCDD dissolved in embryo rearing solution[7] resulted in dose-dependent mortality.

Chemically induced cardiovascular defects in developmental stages of vertebrates: dose-response and phenotypic comparisons in medaka and zebrafish exposed to aryl hydrocarbon receptor agonists

At the end of the experiment, two mice (from the LFD subgroups) displayed abnormalities (ex: immobility, tremors) and were excluded from the analyses [final group sizes: LFD-fed mice (LF-ctrl, n = 13); LFD-fed mice exposed to TCDD (LF-tcdd, n = 15); HFD-fed mice (HF-ctrl, n = 14); and HFD-fed mice exposed to TCDD, (HF-tcdd, n = 16)].

Chronic exposure to low doses of dioxin promotes liver fibrosis development in the C57BL/6J diet-induced obesity mouse model

In 2013, the Ankara Public Prosecutor's Office kicked off an investigation into the tenders of high-speed train projects and began an investigation into the tenders conducted by two TCDD regional directorates between 2009 and 2014.

Prosecutor orders destruction of evidence in state railways case

The 250-km new line will be put into service later this month, TCDD officials said.

TURKEY-TRANSPORTATION -Turkey's state railways to launch new high-speed line

Given the documented adverse effects on the adult rat reproductive tract after a single in utero exposure to TCDD, developmental exposure and differences in the half-life of TCDD could have important consequences for the relevance of results from animal studies for human health.

Mudancas induzidas por dioxina na contagem epididimal de esperma e espermatogenese

In the men with highest TCDD exposure, only 38 percent of their subsequent children were boys.

Dioxin cuts the chance of fathering a boy

A study of mice exposed to TCDD as adults demonstrated that AHR activation had adverse effects on long-term self-renewal (Sakai et al.

Effects of developmental activation of the aryl hydrocarbon receptor by 2,3,7,8-tetrachlorodibenzo-p-dioxin on long-term self-renewal of murine hematopoietic stem cells

yZMyR (CyHAN)- Prosecutor Ali Ecelik, who was investigating the tender-rigging probe into Turkish State Railways (TCDD) yzmir Port, was removed from his post and assigned to another city by the government on Friday.