During the study, the following tests were performed on our subjects: fluorescein staining test on both eyes, lissamine dye staining test on both eyes, TBUT
test on both eyes, and Schirmer test on both eyes (Table 1).
7%) patients had clinically significant dry eye by OSS, Schirmer test and TBUT
Limitation of this study are the variable repeatability and reliability of the Schirmer and TBUT
tests, a relatively short follow-up period and a study design that was not prospective.
On evaluating TBUT
score, nearly 80% patients showed improvement at the end of 3 months.
At the end of study period (12 weeks), intergroup comparison between the study groups was done for the Schirmer's test values, TBUT
test values, and OSDI score (Figure 1), which showed significant difference (p < 0.
Baseline characteristics of all the patients enrolled for the study in reference to Schirmer's and TBUT
test were similar in the two groups as shown in Table 2.
Taking Schirmer\'s test as the gold standard, sensitivity of the TBUT
test was found to be 88.
19,20) In the present study we applied the OSDI, Schirmer test and TBUT
analysis in order to evaluate the tendency of OSAS patients toward dry eyes.
All the patients filled OSDI questionnaire before and after twelve weeks of treatment and objective parameters studied for efficacy of treatment were TBUT
, Rose Bengal Staining and Schirmer 1 Test with anaesthesia.
is typically measured invasively following the instillation of sodium fluorescein dye into the eye, although it is recognised that the presence of the dye can destabilise the tear film, impacting on the accuracy of results.
Patients with TBUT
less than 10 seconds are classified with clinical dry eye.
The dichotomy of presenting signs and symptoms of dry eye during the menstrual cycle is demonstrated by a study which found symptoms to be increased in the luteal phase of the menstrual cycle, whereas TBUT
and inflammation were worse in the follicular phase.