TBK1


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TBK1

A gene on chromosome 12q14.1 that encodes TANK-binding kinase 1, which is similar to I-kappa-B (IKB) kinases and can mediate NF-kappa-B (NFKB) complex activation in response to certain growth factors.
References in periodicals archive ?
Searching through the enormous database generated in the ALS study, the researchers found several genes that appear to contribute to ALS, most notably TBK1, which had not been detected in previous, smaller-scale studies.
TBK1 mutations appeared in about one percent of the ALS patients--a large proportion in the context of a complex disease with multiple genetic components, according to Goldstein.
Using high-throughput chemical screening at LSI's Center for Chemical Genomics to search for compounds that inhibit IKKE and TBK1, the researchers hit upon an approved off-patent drug: amlexanox.
Of the six compounds, luteolin was the most effective inhibitor of TBK1.
What they found was a part of the malaria genome containing a dense portion of the nucleic acids adenine and thymine, two of the building blocks in DNA, which were responsible for activating a novel signalling pathway, including STING, TBK1 and IRF3-IRF7, in the host that enabled innate immune cells to produce type 1 interferon.
They found that those animal models, which expressed the normal STING, TBK1 and IRF3-IRF7 pathway, all succumbed to the infection within 12 days.