TBP

(redirected from TATA box binding protein)
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TBP

Abbreviation for thyroxine-binding protein.
Farlex Partner Medical Dictionary © Farlex 2012

TBP

A gene on chromosome 6q27 that encodes a general transcription factor which acts at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the first transcription step of the pre-initiation complex, and plays a role in activating eukaryotic genes transcribed by RNA polymerase II. TBP is a component of the transcription factor SL1/TIF-IB complex, which is involved in assembling the pre-initiation complex during RNA polymerase I-dependent transcription.

Molecular pathology
Defects of TBP—expansion of a CAG repeat in the coding region—cause spinocerebellar ataxia type 17; the longer the expansion, the earlier the onset and the more severe the clinical disease.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
TATA box binding protein (TBP) was the selected housekeeping gene.
The proteins were detected after an overnight incubation of the membrane at 4[degrees]C with the specific primary antibodies against HDAC1 (dilution 1:1000), Tata box binding protein (Tbp, dilution 1: 1000), [beta]-actin (dilution 1: 5000), HDAC3 (dilution 1:1000), and Chop (dilution 1:500) in buffer containing 0.1% Tween 20 with either 5% milk (for HDAC1, Chop, [beta]-actin, and Tbp) or 5% BSA (for HDAC3 and Atf3).
(5) Human genes: TBP, TATA box binding protein; UBC, ubiquitin C; SDHA, succinate dehydrogenase complex, subunit A, flavoprotein (Fp); RLP13, receptor like protein 13; YHWAZ, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide; HMBS, hydroxymethylbilane synthase; B2M, fi-2 microglobin; hypoxanthine phosphoribosyltransferase 1; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; RPS18, ribosomal protein S18; ACTB, actin, beta; GSS, glutathione synthetase (hGus); 36B4, acidic ribosomal phosphoprotein P0.