TATA box


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Related to TATA box: CAAT box

TATA box

a highly conserved bacterial DNA sequence found about 25 bp upstream from the transcription start site of genes, usually flanked by GC-rich sequences; binding site of transcription factors but not RNA polymerase.

TATA box

or

Hogness box

a short CONSENSUS SEQUENCE generally to be found in the PROMOTOR in EUKARYOTES. The sequence consists of seven or eight NUCLEOTIDES: 5′-TATA(A/T)A(A/T)-3′. It is located about 25 to 30 base pairs UPSTREAM of the start of the TRANSCRIPTION site and serves as a binding site for RNA POLYMERASE. It is similar to the PRIBNOW BOX in PROKARYOTES.

TATA box

a eukaryotic DNA sequence usually TATAAATA, similar to the Pribnow box of Escherichia coli, occurring in the promoter region 25 to 35 bases upstream from the transcriptional start site that binds the general transcription factor TFIID which begins the formation of the transcription initiation complex which includes RNA polymerase.
References in periodicals archive ?
For construction of luciferase vector containing only promoter (-2,657 to +39) of porcine [beta]-casein gene, PCR was conducted using porcine [beta]-casein 5' arm DNA containing normal TATA or mutant TATA box as a template.
Hoechst 33342 induces apoptosis and alters TATA box binding protein/DNA complexes in nuclei from BC3H-1 myocytes.
Among 93 patients with the six-pair TATA box, 14, or 15%, experienced severe side effects from irinotecan hydrochloride.
Likewise, when saddle-shaped yeast TBP binds to DNA containing the TATA box, it causes that DNA to bend sharply in two places and the base pairs in between to lose their helical twist, says Paul B.
Distribution of the genotypes within the TATA box of the UGT1A1 gene and relative risks of MI in the different groups.