TATA box


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Related to TATA box: CAAT box

TATA box

a highly conserved bacterial DNA sequence found about 25 bp upstream from the transcription start site of genes, usually flanked by GC-rich sequences; binding site of transcription factors but not RNA polymerase.

TATA box

or

Hogness box

a short CONSENSUS SEQUENCE generally to be found in the PROMOTOR in EUKARYOTES. The sequence consists of seven or eight NUCLEOTIDES: 5′-TATA(A/T)A(A/T)-3′. It is located about 25 to 30 base pairs UPSTREAM of the start of the TRANSCRIPTION site and serves as a binding site for RNA POLYMERASE. It is similar to the PRIBNOW BOX in PROKARYOTES.
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Literature EST N-mer TATA box CAAT box GC box [13] [check] [14] [check] [15] [check] [check] [check] [16] [check] [check] [17] [check] [9] [8] [check] [18] [10] [11] [19] [20] [7] Literature CpG Conservation TFBS DNase I Histone island marker [13] [14] [15] [16] [check] [check] [17] [check] [9] [check] [8] [check] [check] [18] [check] [10] [11] [19] [20] [check] [check] [7] [check] [check] [check] [check] Literature Pol II Nucleosome [13] [14] [15] [16] [17] [9] [8] [18] [10] [check] [11] [check] [19] [check] [20] [check] [7] [check]
However, the novel observation of one such point mutation that creates an active Spi-B binding site (AAAAGGGAAGG[G.bar]A), directly adjacent to the archetype TATA box, which convert archetype to a biologically active virus, capable of expressing both TAg mRNA and TAg protein significantly increased levels over wild type [121].
A typical TATA box was present at -32 and potential sites of C/EBPp (CCAAT/Enhancer-Binding Protein [beta]) are present at -1,846 and -2,110 (data not shown).
Effects of minor groove binding drugs on the interaction of TATA box binding protein and TFIIA with DNA.
The team concluded that patients with the seven-pair TATA box have a higher probability of suffering serious side effects from the agent.
Likewise, when saddle-shaped yeast TBP binds to DNA containing the TATA box, it causes that DNA to bend sharply in two places and the base pairs in between to lose their helical twist, says Paul B.
Distribution of the genotypes within the TATA box of the UGT1A1 gene and relative risks of MI in the different groups.