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In the intervention group, individuals were genotyped for variants that affect caffeine metabolism (CYP1A2), vitamin C utilization (GSTT1 and GSTM1), sweet taste perception (TAS1R2) and sodium-sensitivity (ACE), and were provided with DNA-based dietary advice for each of these dietary components while the control group was given standard dietary advice but no genetic information.
So mutations in that sweet detector gene, Tas1r2, could easily spread through populations, Beauchamp and colleagues propose in the March 27 Proceedings of the National Academy of Sciences.
Washington, Sep 23 (ANI): A new study has hypothesized that genetic variation in taste pathway genes (TAS2R38, TAS1R2, GNAT3) may be associated with dental caries risk and/or protection.
Statistically significant associations were seen in TAS2R38 and TAS1R2 for caries risk and/or protection.
The researchers correlated the scores with variations in two sugar-sensing genes, TAS1R3 and TAS1R2, and found two variants just outside of the TAS1R3 gene that seemed to predict their volunteer's scores.