In the intervention group, individuals were genotyped for variants that affect caffeine metabolism (CYP1A2), vitamin C utilization (GSTT1 and GSTM1), sweet taste perception (TAS1R2
) and sodium-sensitivity (ACE), and were provided with DNA-based dietary advice for each of these dietary components while the control group was given standard dietary advice but no genetic information.
So mutations in that sweet detector gene, Tas1r2
, could easily spread through populations, Beauchamp and colleagues propose in the March 27 Proceedings of the National Academy of Sciences.
Washington, Sep 23 (ANI): A new study has hypothesized that genetic variation in taste pathway genes (TAS2R38, TAS1R2, GNAT3) may be associated with dental caries risk and/or protection.
Statistically significant associations were seen in TAS2R38 and TAS1R2 for caries risk and/or protection.
The researchers correlated the scores with variations in two sugar-sensing genes, TAS1R3 and TAS1R2
, and found two variants just outside of the TAS1R3 gene that seemed to predict their volunteer's scores.