CACNG2

(redirected from TARP gamma-2)

CACNG2

A gene on chromosome 22q13.1 that encodes a gamma subunit of a voltage-dependent calcium channel, which regulates AMPA-selective glutamate receptor (AMPAR) trafficking and gating. It promotes
AMPAR targeting to the cell membrane and synapses, and it modulates their gating properties by slowing their activation, deactivation and desensitisation.
References in periodicals archive ?
It was known that a protein on the cell surface called TARP gamma-2, also known as stargazing, interacts with a brain cell receptor called AMPA, ensuring the receptor finds the cells surface.
Inside the nucleus of inhibitory cells in areas of the brain that control learning and memory, the researchers found erbin interacts with TARP gamma-2, enabling it to survive.
When scientists ablated the erbin gene in mice or kept erbin from interacting with TARP gamma-2, a protein that helps anchor the AMPA receptor on the cell surface, TARP gamma-2 couldn't do its job.