TAP2


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TAP2

A gene on chromosome 6p21.3 that encodes a member of the MDR/TAP subfamily of the superfamily of ATP-binding cassette (ABC) transporters, which plays a role in multidrug resistance and antigen presentation. TAP2 forms a heterodimer with ABCB2 in order to transport peptides from the cytoplasm to the endoplasmic reticulum.

Molecular pathology
TAP2 mutations have been tentatively linked to ankylosing spondylitis, type-1 diabetes and coeliac disease.
References in periodicals archive ?
Healthy controls were subjected to HWE for rs116076690, rs2071543 in PSMB8 , rs17587 in PSMB9 , rs1135216 in TAP1 , and rs2228391, rs2228396, rs241447, rs241448, and rs4148876 in TAP2 (df = 1, P > 0.
The main finding of this study was that only rs17587-G/G at PSMB9 may increase a risk of PD for Chinese female besides other identified SNPs variants in PSMB8, PSMB9, TAP1, and TAP2 genes.
TAP1 and TAP2 belong to an ATP-binding cassette family, transporting small antigenic peptides into the lumen of the endoplasmic reticulum.
The PSMB8 , PSMB9 , TAP1 , and TAP2 genes at chromosome 6 are located at an adjacent range from 32.
In summary, we evaluated the association of SNPs in PSMB and TAP with PD and found: (i) no linkage was revealed between SNPs at PSMB8 , TAP1 , and TAP2 and PD (ii) the rs17587-G at PSMB9 may develop an increased risk of PD for Chinese female population.
20) This model, which uses the B16F10 cell line, is widely used to evaluate T-cell-based vaccine strategies, as it is a highly metastatic and poorly immunogenic cell line and is defective in levels of TAP1 and TAP2.