TAP2


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TAP2

A gene on chromosome 6p21.3 that encodes a member of the MDR/TAP subfamily of the superfamily of ATP-binding cassette (ABC) transporters, which plays a role in multidrug resistance and antigen presentation. TAP2 forms a heterodimer with ABCB2 in order to transport peptides from the cytoplasm to the endoplasmic reticulum.

Molecular pathology
TAP2 mutations have been tentatively linked to ankylosing spondylitis, type-1 diabetes and coeliac disease.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
The PRICE Turnaround Programme consisted of two rounds of interventions, TAP1 and TAP2, each lasting two years.
Escherichia coli Sample Coliforms (Log Cfu/ml) (Log Cfu/ml) TAP5 200 [+ or -] 4.9a 0.0 [+ or -] 0.0a TAP4 430 [+ or -] 10.8a 23 [+ or -] 0.67c TAP3 710 [+ or -] 23.6a 13 [+ or -] 1.9b TAP1 0.0 [+ or -] 0.0a 0.0 [+ or -] 0.0a TAP2 15000 [+ or -] 45.3b 0.0 [+ or -] 0.0a Mean 3268 7.2 cv % 19.5 16.7 Clostridium pafringens Staphylococcus aureus Sample (Log Cfu/ml) (Log Cfu/ml) TAP5 0.0 [+ or -] 0.0a 475 [+ or -] 30.67b TAP4 0.0 [+ or -] 0.0a 0.0 [+ or -] 0.0a TAP3 0.0 [+ or -] 0.0a 0.0 [+ or -] 0.0a TAP1 775.0 [+ or -] 59.5b 125.7 [+ or -] 8.09b TAP2 12.5 [+ or -] 1.71a 75.0 [+ or -] 4.69b Mean 157.5 135.14 cv % 10.7 6.4 (1) Values are means of two determinations [+ or -] standard deviations.
The SNaPshot genotyping (Applied Biosystems Co., Foster City, CA, USA) of rs116076690, rs2071543 in PSMB8 , rs17587 in PSMB9 , rs1135216 in TAP1 , and rs2228391, rs2228396, rs241447, rs241448, and rs4148876 in TAP2 were shown in [Supplement Table 1].
Nezamdoost, "TAP2 polymorphisms in Iranian patients with type I diabetes mellitus," International Journal of Genetics and Molecular Biology, vol.
Details of these studies were published in a series of landmark publications, which also demonstrated that TAP1 and TAP2 gene transfer could also improve the potency of vaccines for the treatment of viral diseases.
TAP, a heterodimeric protein consisting of TAP1 and TAP2 subunits, is located on the ER membrane, belonging to one of the ATP-binding cassette (ABC) transporter members [28].
These chaperone-like proteins in MHC-I processing pathway include the transporter associated with antigen processing (TAP1 & TAP2), tapasin, calnexin, calreticulin, and ERp57 Engrafted donor skins showed significant upregulation of TAP1, but only marginal upregulation of TAP2 (Figure 3).
Nonresponders were more likely homozygous at a specific amino acid position of TAP2.
Lin et al., "Association between polymorphisms of PSMB8, PSMB9 and TAP2 genes with rheumatoid arthritis in ethnic Han Chinese from Yunnan," Zhonghua Yi Xue Yi Chuan Xue Za Zhi, vol.
In particular, SNPs in the LMP7, TAP2, and ERAP1 have been found to be associated with cervical carcinoma risk, lymph node metastases, and overall survival, both individually and in specific haplotype configurations [41, 45].
This process requires the transporter associated with antigen processing 1 (TAP1), TAP2, and different ER-resident chaperons such as calnexin, calreticulin, and tapasin [55, 56].