TAP2


Also found in: Acronyms.

TAP2

A gene on chromosome 6p21.3 that encodes a member of the MDR/TAP subfamily of the superfamily of ATP-binding cassette (ABC) transporters, which plays a role in multidrug resistance and antigen presentation. TAP2 forms a heterodimer with ABCB2 in order to transport peptides from the cytoplasm to the endoplasmic reticulum.

Molecular pathology
TAP2 mutations have been tentatively linked to ankylosing spondylitis, type-1 diabetes and coeliac disease.
Mentioned in ?
References in periodicals archive ?
Healthy controls were subjected to HWE for rs116076690, rs2071543 in PSMB8 , rs17587 in PSMB9 , rs1135216 in TAP1 , and rs2228391, rs2228396, rs241447, rs241448, and rs4148876 in TAP2 (df = 1, P > 0.
The main finding of this study was that only rs17587-G/G at PSMB9 may increase a risk of PD for Chinese female besides other identified SNPs variants in PSMB8, PSMB9, TAP1, and TAP2 genes.
TAP1 and TAP2 belong to an ATP-binding cassette family, transporting small antigenic peptides into the lumen of the endoplasmic reticulum.
The PSMB8 , PSMB9 , TAP1 , and TAP2 genes at chromosome 6 are located at an adjacent range from 32.
In summary, we evaluated the association of SNPs in PSMB and TAP with PD and found: (i) no linkage was revealed between SNPs at PSMB8 , TAP1 , and TAP2 and PD (ii) the rs17587-G at PSMB9 may develop an increased risk of PD for Chinese female population.
Association Analysis of Proteasome Subunits and Transporter Associated with Antigen Processing on Chinese Patients with Parkinson's Disease
20) This model, which uses the B16F10 cell line, is widely used to evaluate T-cell-based vaccine strategies, as it is a highly metastatic and poorly immunogenic cell line and is defective in levels of TAP1 and TAP2.
Tap: novel targets for cancer vaccine development

Medical browser ?
Full browser ?