TAP1


Also found in: Acronyms.

TAP1

A gene on chromosome 6p21.3 that encodes a member of the MDR/TAP subfamily of the superfamily of ATP-binding cassette (ABC) transporters, which plays a role in multidrug resistance. TAP1 pumps degraded cytosolic peptides across the endoplasmic reticulum into the membrane-bound compartment.

Molecular pathology
TAP1 mutations have been tentatively linked to ankylosing spondylitis, type 1 diabetes and coeliac disease.
References in periodicals archive ?
The main finding of this study was that only rs17587-G/G at PSMB9 may increase a risk of PD for Chinese female besides other identified SNPs variants in PSMB8, PSMB9, TAP1, and TAP2 genes.
TAP1 and TAP2 belong to an ATP-binding cassette family, transporting small antigenic peptides into the lumen of the endoplasmic reticulum.
The PSMB8 , PSMB9 , TAP1 , and TAP2 genes at chromosome 6 are located at an adjacent range from 32.
18) The researchers demonstrated that a nonreplicating adenovirus encoding the gene for TAP1 (AdhTAP1) could restore TAP1 expression in the mouse lung carcinoma cell line CMT.
Collectively, these studies show that TAP1 gene transfer and expression of small amounts of TAP results in several critical effects:
As a prerequisite for entry into the clinic the reproducible manufacturing and safety of TAP1 constructs needs to be established.