TAP1


Also found in: Acronyms.

TAP1

A gene on chromosome 6p21.3 that encodes a member of the MDR/TAP subfamily of the superfamily of ATP-binding cassette (ABC) transporters, which plays a role in multidrug resistance. TAP1 pumps degraded cytosolic peptides across the endoplasmic reticulum into the membrane-bound compartment.

Molecular pathology
TAP1 mutations have been tentatively linked to ankylosing spondylitis, type 1 diabetes and coeliac disease.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
The PRICE Turnaround Programme consisted of two rounds of interventions, TAP1 and TAP2, each lasting two years.
Rab et al., "The Unfolded Protein Response (UPR)-activated transcription factor X-box-binding protein 1 (XBP1) induces microRNA-346 expression that targets the human antigen peptide transporter 1 (TAP1) mRNA and governs immune regulatory genes," The Journal of Biological Chemistry, vol.
tap1 <OE tepen; ?<OF taper, strike, or of imitative origin; unrelated to tap2, faucet
(11) The TAP structure is formed of two proteins: TAP1 and TAP2, which assemble into a heterodimer.
La proteina asociada a transporte en el procesamiento de antigenos (TAP) es una proteina compuesta de dos polipeptidos, TAP1 y TAP2.
In vivo expression of HPV18 E7 results in reduced expression of IRF-1 target gene such as TAP1, IFN-[beta] and MCP-1 by inhibition of the transactivating function of IRF-1 (62).
Or, you might simply want to connect the first net to TAP2 and the second net to TAP1. Applications modified in this way must be regenerated to register the changes.
a tomato anionic peroxidase gene (tap1) by wounding in transgenic
C1R-B*27:04 cells (3 x [10.sup.6] cells/ well) with TAP1 knockdown were maintained in the same medium with 0.4 [micro]g/ml puromycin.
Suri, "No association of TAP1 and TAP2 genes polymorphism with risk of cervical cancer in north Indian population," Journal of Assisted Reproduction and Genetics, vol.
Methods: A case–control study was conducted by genotyping SNPs in PSMB8, PSMB9, TAP1, and TAP2 genes in the Chinese population.