TAOK3A gene on chromosome 12q that encodes a ubiquitously expressed serine/threonine-protein kinase, which upregulates the p38/MAPK14 cascade in response to stress and DNA damage. It downregulates the MAPK8/JNK cascade and reduces its activation in response to epidermal growth factor. It is highly expressed in peripheral white cells, thymus, spleen, kidneys, skeletal muscle, heart and liver.
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