TAOK2


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TAOK2

A gene on chromosome 16p11.2 that encodes a ubiquitous serine/threonine-protein kinase, which is involved in membrane blebbing and apoptosis, DNA damage response and the MAPK14/p38 stress-activated cascade. TAOK2 phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. It is highly expressed in the testes and brain.
References in periodicals archive ?
Interactions of Receptor Nrp1 and Secreted Guidance Cue Sema 3A with TAOK2
It was found that TAOK2 interacts with this pathway to modulate neuronal differentiation.
Activated TAOK2 leads to stimulation of the JNK pathway.
These observations, considered collectively, constitute evidence that Sema3A, TAOK2 and JNK act in the same pathway to modulate neuronal differentiation in cortical pyramidal neurons.
A part of this review was dedicated to the consideration of a TAOK2 mediated mew molecular pathway that preferentially modulates the formation of basal dendrites in cortical pyramidal neurons.