TAOK1

TAOK1

A gene on chromosome 17q11.2 that encodes a serine/threonine-protein kinase, which regulates the p38/MAPK14 stress-activated cascade, DNA damage response at the G2/M transition DNA damage checkpoint, and cytoskeleton stability. TAOK1 also regulates apoptosis by activating the MAPK8/JNK cascade. It is highly expressed in the testes.
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References in periodicals archive ?
TAOK1 and TAOK2 serine/threonine protein kinases are known to activate MAPK pathways (JNK, p38 or extracellular signal-regulated kinase), leading to the modulation of gene transcription.