TAF1

TAF1

A gene on chromosome Xq13.1 that encodes TAF1 RNA polymerase II, the activation of which requires the co-ordinated activity of over 70 poypeptides. TAFs (TATA-binding protein-associated factors) are thought to participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors to facilitate polypeptide complex assembly and transcription initiation. TAF1 phosphorylates TP53, leading to its MDM2-mediated degradation; phosphorylates GTF2A1 and GTF2F1 on Ser residues; binds DNA; and is essential for progression of the G1 phase of the cell cycle.
Mentioned in ?
References in periodicals archive ?
Clinical exome sequencing considering 4800 human genes including 18 genes related to Parkinson's disease (PARK1: SNCA; PARK2: PRKN; PARK3: SPR; PARK4: SNCA Dup/Del; PARK5: UCHL1; PARK6: PINK1; PARK7: DJ1; PARK8: LRRK2; PARK9: ATP13A2; PARK10: ELAVL4; PARK11: GIGYF2; PARK12: TAF1; PARK13: HTRA2; PARK14: PLA2G6; PARK15: FBXO7; PARK16: ADORAI; PARK17: VPS35; PARK18: EIF4GI) (TruSight One Sequencing Panels, Illumina) were performed on MiSeq platform (Illumina).
The preheating device was designed using Solid Works; the design was constructed with keeping the specifications of the Kirloskar TAF1 engine.
Disruptions in NF-protocadherin and TAF1 can lead to a shortened AP axis that was not evident until stages 22-25, some time after neural tube closure [305].
The Fund will build on the Trade Advocacy Fund (TAF1) which provided on-demand technical assistance to developing countries to participate in trade negotiations.
Other genes that have emerged as significantly mutated genes in whole-exome sequencing studies of serous endometrial carcinomas are SPOP, a putative tumor suppressor gene; CDKN1A [cyclin-dependent kinase inhibitor 1A (p21, Cip1)], a bona fide cancer gene; TAF1; HCFC1R1 [host cell factor C1 regulator 1 (XPO1 dependent)]; CTDSPL [CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like]; YIPF3 (Yip1 domain family, member 3); and FAM132A (family with sequence similarity 132, member A) (17, 18).
Ando et al., "Reduced Neuron-Specific Expression of the TAF1 Gene Is Associated with X-Linked Dystonia-Parkinsonism," American Journal of Human Genetics 80 (2007): 293-406.