EPCAM

(redirected from TACSTD1)

EPCAM

A gene on chromosome 2p21 that encodes a carcinoma-associated antigen expressed on most normal epithelial cells and gastrointestinal carcinomas, which functions as a homotypic calcium-independent cell adhesion molecule. EPCAM is thought to function as a relay molecule between intestinal epithelial cells and intraepithelial lymphocytes at the mucosa, providing an immune barrier to infection. It is of interest in oncology as a target for cancer immunotherapy. It upregulates expression of FABP5, MYC and cyclins A and E.

Molecular pathology
Defects in EPCAM cause congenital tufting enteropathy (diarrhoea type 5).

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References in periodicals archive ?

Patients with an MSI-H phenotype in their cancer tissues may have a germline mutation in 1 of several DNA MMR genes (eg, MLH1, MSH2, MSH6, or PMS2) or an altered EPCAM (TACSTD1) gene.

Heritable somatic methylation and inactivation of MSH2 in families with Lynch syndrome due to deletion of the 30 exons of TACSTD1. Nat Genet.

Template for Reporting Results of Biomarker Testing of Specimens From Patients With Carcinoma of the Endometrium

The characterized 13 DEGs (2-fold up-regulated), such as v-myb avian myeloblastosis viral oncogene homolog (MYB), recombination activating gene-1 (RAG-1), epithelial cell adhesion molecule (TACSTD1), Secale cereale 75k gamma secalin gene (75k gamma secalin ), snRNA (U6), microRNA mir-155 (ssc-mir-155), microRNA let-7c (ssc-let-7c), NCK interacting protein with SH3 domain/cadherin, EGF LAG seven-pass G-type receptor 3 (CELSR3,NCKIPSD), cAMP-regulated phosphoprotein, 21kDa (ARPP21), interleukin 20 receptor beta (IL20RB), DNA nucleotidylexotransferase (DNTT), collagen, type V, alpha 2 (COL5A2), and microRNA mir-374a/microRNA mir-374b/microRNA mir-421/microRNA mir-545 (ssc-mir-374a) are shown in Supplementary Table I.

Short Communication - RNA-Seq Reveals Differentially Expressed Genes of Pig Vaccinated with Modified Live Attenuated Porcine Epidemic Diarrhea

In a subset of LS patients, a germline mutation at the 3' end of the EPCAM (TACSTD1) gene has been identified resulting in allelic-specific methylation and transcription silencing of MSH2, which is located upstream of the EPCAM gene.

Novel Implications in Molecular Diagnosis of Lynch Syndrome

Briefly, reactions were performed with a probe concentration of 200 nmol/L and a 60-s anneal/extend phase at 60 [degrees]C for GUSB, [5] CK19, CK20, EGFR, MGB1, PTHrP, SCCA, and SFTPB; 62 [degrees]C for CK7, MAGEA-plex, MART1, and MGB2; and 64 [degrees]C for CEA, LUNX, PIP, TACSTD1, TM4SF3, and TYR.

When we used median expression in the tumors as the numerator (median tumor/highest normal), 6 genes (CK7, CK19, TACSTD1, MGB1, MGB2, and PIP) for breast cancer, 5 genes (CEA, CK19, CK20, TACSTD1, and TM4SF3) for colon cancer, 6 genes (CEA, CK19, CK7, TACSTD1, CK20, and TM4SF3) for esophageal cancer, 4 genes (CEA, CK19, SCCA, and PTHrP) for head and neck cancer, 7 genes (CEA, CK7, CK19, LUNX, SCCA, SFTPB, and TACSDT1) for lung cancer, and 3 genes (MAGEA-plex, MART1, and TYR) for melanoma clearly stood out as having mean tumor:highest normal blood ratios ~1500-25,000.

Similarly, the best 2- to 4-marker combination for the other cancer types would be TM4SF3 and TACSTD1 for colon cancer (100% of 28 tumors >1000-fold; minimum, 1.23 x [10.sup.3]), TM4SF3 and CK7 for esophageal cancer (89.5% of 19 tumors; 4.64 x [10.sup.2]), PTHrP, EGFR, and SCCA for head and neck cancer (100% of 26 tumors; 3.28 x [10.sup.3]), CK7, EGFR, SCCA, and SFTPB for lung cancer (100% of 22 tumors; 2.26 x [10.sup.3]), and MAGEA-plex, MART1, and TYR for melanoma (100% of 24 tumors; 3.27 x [10.sup.3]).

Optimal markers for real-time quantitative reverse transcription PCR detection of circulating tumor cells from melanoma, breast, colon, esophageal, head and neck, and lung cancers

Five of these genes--CDX1, CEA, CK19, TACSTD1, and Villin1 (VIL1)--have median tumor/highest benign node ratios >300 and therefore have the potential to detect small foci of tumor while still differentiating negative nodes.

On the basis of expression results in positive nodes and distribution of expression in benign nodes, TACSTD1 expression was, at a minimum, 595-fold higher in positive nodes than the highest expression in benign nodes.

Identification of mRNA markers for molecular staging of lymph nodes in colorectal cancer

Patients with a microsatellite instability-high (MSI-H) phenotype that indicates MMR deficiency in their cancer may have a germline mutation in 1 of several DNA MMR genes (eg, MLH1, MSH2, MSH6, or PMS2) or an altered EPCAM (TACSTD1) gene.

Template for Reporting Results of Biomarker Testing of Specimens From Patients With Carcinoma of the Colon and Rectum

(24-26) Recently, deletions of the 3' portion of a gene upstream of MSH2, EPCAM (previously known as TACSTD1), have been identified as a cause of constitutional epigenetic inactivation of MSH2 in a subset of families affected by LS.

Heritable somatic methylation and inactivation of MSH2 in families with Lynch syndromedue to deletion of the 3' exons of TACSTD1. Nat Genet.