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ADAM1bha17An ADAMs family protein encoded by ADAM17 on chromosome 2p25, which acts as a tumour necrosis factor-alpha converting enzyme (TACE). It binds mitotic arrest-deficient 2 protein, and plays a key role in activating Notch signalling, resulting in the proteolytic release of cell-surface proteins, including p75 TNF-receptor, IL-1 receptor type II, p55 TNF-receptor, TGF-alpha, L-selectin, growth hormone receptor, MUC1 and amyloid precursor protein (APP).
transcatheter arterial chemoembolization(trans″kath′ĕt-ĕr),
A technique for destroying tumors in which a tube is guided into the arterial blood supply of the tumor and drugs, fragments of muscle, or synthetic spheres are introduced to obstruct the artery. It is used to treat liver cancers that cannot be removed surgically.