TAC1


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TAC1

A gene on chromosome 7q21-q22 that encodes four different tachykinins—substance P, neurokinin A, neuropeptide K and neuropeptide gamma—which are thought to function as neurotransmitters, interacting with nerve receptors and smooth muscle cells, inducing behavioural responses and acting as vasodilators and secretagogues.
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Mice with inactivated Tac1 neurons had normal withdrawal reflexes when exposed to a painful stimulus.
Similarly, mice with disabled Tac1 neurons showed no pain-coping responses when their hind paws were pinched -- something that induces sustained pain in humans.
These observations confirm that Tac1 neurons are critical for pain-coping behaviors stemming from sustained irritation or injury but that they play no role in reflexive-defensive reactions to external threats.
Soong et al., "Postoperative serum methylation levels of TAC1 and SEPT9 are independent predictors of recurrence and survival of patients with colorectal cancer," Cancer, vol.
Koishi et al., "Tachykinin 1 (TAC1) gene SNPs and haplotypes with autism: a case-control study," Brain & Development, vol.
* TAC1 : The way our technology works can easily be described in manuals.
The future UEx G6 staff includes an O-4, FA53 in TAC1 and an O-3, FA53 in TAC2.
At the time of the development of the modularity design, at a conference at Fort Leavenworth, the G6 was limited to 32 authorized positions as its share of the limited number of positions in the Division Main, Division TAC1 and DTAC2.