TAAR1

TAAR1

A gene on chromosome 6q23.2 that encodes a G protein-coupled receptor activated by trace amines. Trace amines are endogenous compounds that account for less than 1% of the biogenic amines in most brain regions, and are thought to have a role in neurotransmission.
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13) Presumably, the low level of intracellular exposure mitigates the risk of excessive TAAR1 agonism, but amphetamine derivatives should be approached cautiously and with careful blood pressure monitoring.
Symbol Entrez gene name PDE3A Phosphodiesterase 3A, cGMP-inhibited PIK3C2G Phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma PDE11A Phosphodiesterase 11A MC4R Melanocortin 4 receptor PDE4D Phosphodiesterase 4D, cAMP-specific TAAR1 Trace amine associated receptor 1 CNR1 Cannabinoid receptor 1 (brain) RGS18 Regulator of G-protein signaling 18 ADRA2B Adrenoceptor alpha 2B CALCR Calcitonin receptor AVPR1A Arginine vasopressin receptor 1A ADCY2 Adenylate cyclase 2 (brain) Symbol Fold change Location Type(s) PDE3A 9.
Activation of TAAR1 by tyramine is an important part of the hypertensive effects related to excessive tyramine exposure.