Although the exact mechanism of action is unknown, SEP-363856 is believed to activate
TAAR1 (trace amine-associated receptor 1) in addition to 5-HT1A (serotonin 1A) receptors.
Miller, Avenues for the development of therapeutics that target trace amine associated receptor 1 (
TAAR1), J.
The only theoretical sources of concern for pressor effects are medications that act as norepinephrine releasers through interactions at the trace amine-associated receptor 1 (
TAAR1) (for more information on
TAAR1, see "A concise guide to monoamine inhibitors," CURRENT PSYCHIATRY.
(16) Unlike the dextro isomers, L-amphetamine structures do not inhibit dopamine reuptake or cause euphoria, but can cause stimulation (eg, sleep disturbance) by inhibiting norepinephrine reuptake, and also by interacting with the trace amine-associated receptor 1 (
TAAR1), an intracellular receptor expressed within the presynaptic terminal of monoamine neurons.