TAAR1

A gene on chromosome 6q23.2 that encodes a G protein-coupled receptor activated by trace amines. Trace amines are endogenous compounds that account for less than 1% of the biogenic amines in most brain regions, and are thought to have a role in neurotransmission.

References in periodicals archive ?

Although the exact mechanism of action is unknown, SEP-363856 is believed to activate TAAR1 (trace amine-associated receptor 1) in addition to 5-HT1A (serotonin 1A) receptors.

Sunovion and PsychoGenics Announce that SEP-363856 Has Received FDA Breakthrough Therapy Designation for the Treatment of People with Schizophrenia

Miller, Avenues for the development of therapeutics that target trace amine associated receptor 1 (TAAR1), J.

Molecular Interaction Mechanism of Tyramine, Phenethylamine Binding with Adrenergic Receptor [beta]2

The only theoretical sources of concern for pressor effects are medications that act as norepinephrine releasers through interactions at the trace amine-associated receptor 1 (TAAR1) (for more information on TAAR1, see "A concise guide to monoamine inhibitors," CURRENT PSYCHIATRY.

A concise guide to monoamine oxidase inhibitors: How to avoid drug interactions: Use these strategies to maximize efficacy and minimize adverse effects when prescribing an MAOI

(16) Unlike the dextro isomers, L-amphetamine structures do not inhibit dopamine reuptake or cause euphoria, but can cause stimulation (eg, sleep disturbance) by inhibiting norepinephrine reuptake, and also by interacting with the trace amine-associated receptor 1 (TAAR1), an intracellular receptor expressed within the presynaptic terminal of monoamine neurons.

A concise guide to monoamine oxidase inhibitors: A better understanding of the risks can lead to increased use of these highly effective agents

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