TAAR1

TAAR1

A gene on chromosome 6q23.2 that encodes a G protein-coupled receptor activated by trace amines. Trace amines are endogenous compounds that account for less than 1% of the biogenic amines in most brain regions, and are thought to have a role in neurotransmission.
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References in periodicals archive ?
Although the exact mechanism of action is unknown, SEP-363856 is believed to activate TAAR1 (trace amine-associated receptor 1) in addition to 5-HT1A (serotonin 1A) receptors.
Miller, Avenues for the development of therapeutics that target trace amine associated receptor 1 (TAAR1), J.
The only theoretical sources of concern for pressor effects are medications that act as norepinephrine releasers through interactions at the trace amine-associated receptor 1 (TAAR1) (for more information on TAAR1, see "A concise guide to monoamine inhibitors," CURRENT PSYCHIATRY.
(16) Unlike the dextro isomers, L-amphetamine structures do not inhibit dopamine reuptake or cause euphoria, but can cause stimulation (eg, sleep disturbance) by inhibiting norepinephrine reuptake, and also by interacting with the trace amine-associated receptor 1 (TAAR1), an intracellular receptor expressed within the presynaptic terminal of monoamine neurons.