Cocaine Vaccine

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A vaccine in early stages of development (as of spring 2010) which combines an inactivated cholera toxin B protein with an inactivated cocaine molecule
References in periodicals archive ?
A potential "cocaine vaccine" called TA-CD, which is made from succinyl norcocaine conjugated to cholera toxin, is being evaluated.
La vacuna anticocaina, llamada TA-CD, esta siendo desarrollada por Celtic Pharma.
A vaccine called TA-CD, now under development by Xenova Group PLC, generates antibodies that prevent cocaine from crossing the blood-brain barrier.
A vaccine called TA-CD, under development by Xenova Group PLC, generates antibodies that prevent cocaine from crossing the blood-brain barrier.
In a study of 11 patients, TA-CD, a vaccine under development by Xenova Group PLC, to prevent cocaine from crossing the blood-brain barrier, was associated with reduced cocaine use for 1 year, without major adverse effects, he said.
'A number of addicts receiving the TA-CD vaccine were able to remain abstinent during the study.'
Slough-based Xenova today announced the start of a two-year clinical trial of the TA-CD vaccine involving 132 methadone-dependent addicts.
Xenova vaccine TA-CD, designed to help cocaine addicts quit, has already shown signs in clinical trials of reducing the euphoric effect of taking the drug.
The vaccine - known as TA-CD - works by generating antibodies in the bloodstream which neutralise the effects of the drug.
Therapy for addiction--cocaine addiction (TA-CD) is thought to curb cocaine use by engaging the body's immune reaction and stopping cocaine molecules from reaching the brain, thereby reducing the drug's pleasurable effects.